Impact of Carotid Stent Cell Design on Vessel Scaffolding: A Case Study Comparing Experimental Investigation and Numerical Simulations
Impact of Carotid Stent Cell Design on Vessel Scaffolding: A Case Study Comparing Experimental Investigation and Numerical Simulations
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DOI：
10.1583/10-3338.1
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发表时间：
2011-06-01
影响因子：
2.6
通讯作者：
Odero, Attilio
中科院分区：
文献类型：
--
作者：
Conti, Michele;Van Loo, Denis;Odero, Attilio
目的：通过颈动脉支架置入术 (CAS) 的患者特异性有限元分析，定量评估颈动脉支架细胞设计对血管支架的影响。方法：该研究分为两部分：(1) CAS 患者特异性有限元分析的验证和 (2) 血管支架的评估。将部署在患者特异性硅胶模拟动脉中的开孔支架的微计算机断层扫描 (CT) 图像与相应的有限元分析结果进行比较。对于闭孔对应物重复了该模拟。在第二部分中，对不同血管横截面中的两种细胞类型的支架支柱分布（由支柱间角度反映）进行了评估，作为支架的测量。结果：CAS 患者特异性有限元分析的结果在定性和定量上与实验支架部署良好匹配，证明了数值方法的可靠性。测量的支柱间角度表明，与开孔设计相比，闭孔设计提供了更好的血管支架。然而，闭孔设计的完全支柱互连降低了支架适应血管横截面不规则偏心轮廓的能力，导致支架表面和血管壁之间出现间隙。结论：尽管这项研究仅限于单一支架设计和一种血管解剖结构，但该研究证实了专用计算机模拟预测开孔和闭孔颈动脉支架差异的能力 支架。这些模拟有可能用于新型颈动脉支架的设计或手术规划。 J Endovasc Ther。 2011； 18：397-406
Purpose: To quantitatively evaluate the impact of carotid stent cell design on vessel scaffolding by using patient-specific finite element analysis of carotid artery stenting (CAS).Methods: The study was organized in 2 parts: (1) validation of a patient-specific finite element analysis of CAS and (2) evaluation of vessel scaffolding. Micro-computed tomography (CT) images of an open-cell stent deployed in a patient-specific silicone mock artery were compared with the corresponding finite element analysis results. This simulation was repeated for the closed-cell counterpart. In the second part, the stent strut distribution, as reflected by the inter-strut angles, was evaluated for both cell types in different vessel cross sections as a measure of scaffolding.Results: The results of the patient-specific finite element analysis of CAS matched well with experimental stent deployment both qualitatively and quantitatively, demonstrating the reliability of the numerical approach. The measured inter-strut angles suggested that the closed-cell design provided superior vessel scaffolding compared to the open-cell counterpart. However, the full strut interconnection of the closed-cell design reduced the stent's ability to accommodate to the irregular eccentric profile of the vessel cross section, leading to a gap between the stent surface and the vessel wall.Conclusion: Even though this study was limited to a single stent design and one vascular anatomy, the study confirmed the capability of dedicated computer simulations to predict differences in scaffolding by open-and closed-cell carotid artery stents. These simulations have the potential to be used in the design of novel carotid stents or for procedure planning. J Endovasc Ther. 2011; 18: 397-406