Sonogashira Couplings Catalyzed by Fe Nanoparticles Containing ppm Levels of Reusable Pd, under Mild Aqueous Micellar Conditions
Sonogashira Couplings Catalyzed by Fe Nanoparticles Containing ppm Levels of Reusable Pd, under Mild Aqueous Micellar Conditions
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DOI：
10.1021/acscatal.9b00007
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发表时间：
2019-03-01
期刊：
影响因子：
12.9
通讯作者：
Lipshutz, Bruce H.
中科院分区：
文献类型：
--
作者：
Handa, Sachin;Jin, Bo;Lipshutz, Bruce H.
含有配体XPhos和500 ppm Pd的FeCl3衍生的纳米颗粒在室温至45℃之间的水中影响Sonogashira偶联。整个水性反应介质可以使用“烧瓶内”萃取轻松回收。几个串联过程在一个锅中说明，包括一个序列涉及5个步骤（10个反应）在良好的总体产量。
Nanoparticles derived from FeCl3 containing the ligand XPhos and only 500 ppm Pd effect Sonogashira couplings in water between rt and 45 degrees C. The entire aqueous reaction medium can be easily recycled using an "in-flask" extraction. Several tandem processes in one pot are illustrated, including a sequence involving five steps (10 reactions) in good overall yield.