Effects of Polyphenol, Measured by a Biomarker of Total Polyphenols in Urine, on Cardiovascular Risk Factors After a Long-Term Follow-Up in the PREDIMED Study.
Effects of Polyphenol, Measured by a Biomarker of Total Polyphenols in Urine, on Cardiovascular Risk Factors After a Long-Term Follow-Up in the PREDIMED Study.
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在Predimed研究中长期随访后，多酚的影响，通过尿液中总多酚的生物标志物对心血管危险因素的影响。
DOI：
10.1155/2016/2572606
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发表时间：
2016
影响因子：
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通讯作者：
Lamuela-Raventós RM
中科院分区：
文献类型：
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作者：
Guo X;Tresserra-Rimbau A;Estruch R;Martínez-González MA;Medina-Remón A;Castañer O;Corella D;Salas-Salvadó J;Lamuela-Raventós RM
一些流行病学研究表明，食用富含多酚的食物与心血管疾病风险之间存在负相关。然而，使用尿总多酚排泄（TPE）作为总多酚摄入量的生物标志物可以增加这些研究的准确性和可靠性。我们的目的是评估通过Folin-Ciocalteu检测尿液中的抗氧化活性是否与高风险老年人群中心血管风险因素（血压和血糖、胆固醇、HDL-胆固醇、LDL-胆固醇和甘油三酯浓度）的改善相关。对PREDIMED研究（ISRCTN 35739639）的573例受试者（年龄67.3 ± 5.9岁）进行了一项纵向研究。我们采用Folin-Ciocalteu方法测定尿样中的TPE，辅助固相萃取。根据TPE的变化将参与者分为三组。使用多元线性回归模型评估TPE与临床心血管风险因素之间的关系，并对潜在混杂因素进行调整。5年随访后，TPE的变化与血浆甘油三酯浓度（β = −8.563; P = 0.007）、葡萄糖浓度（β = −4.164; P = 0.036）和舒张压（β = −1.316; P = 0.013）呈显著负相关。我们的研究结果表明，摄入更多的多酚（以尿液中的TPE测量）可以对一些心血管危险因素产生保护作用。
Several epidemiological studies have shown an inverse association between the consumption of polyphenol-rich foods and risk of cardiovascular diseases. However, accuracy and reliability of these studies may be increased using urinary total polyphenol excretion (TPE) as a biomarker for total polyphenol intake. Our aim was to assess if antioxidant activity, measured by a Folin-Ciocalteu assay in urine, is correlated with an improvement in cardiovascular risk factors (blood pressure and serum glucose, cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride concentrations) in an elderly population at high risk. A longitudinal study was performed with 573 participants (aged 67.3 ± 5.9) from the PREDIMED study (ISRCTN35739639). We used Folin-Ciocalteu method to determine TPE in urine samples, assisting with solid phase extraction. Participants were categorized into three groups according to changes in TPE. Multiple linear regression models were used to assess relationships between TPE and clinical cardiovascular risk factors, adjusting for potential confounders. After a 5-year follow-up, significant inverse correlations were observed between changes in TPE and plasma triglyceride concentration (β = −8.563; P = 0.007), glucose concentration (β = −4.164; P = 0.036), and diastolic blood pressure (β = −1.316; P = 0.013). Our results suggest that the consumption of more polyphenols, measured as TPE in urine, could exert a protective effect against some cardiovascular risk factors.