Anomalies in social behaviors and exploratory activities in an APPswe/PS1 mouse model of Alzheimer's disease
Anomalies in social behaviors and exploratory activities in an APPswe/PS1 mouse model of Alzheimer's disease
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DOI：
10.1016/j.physbeh.2011.05.023
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发表时间：
2011-10-24
影响因子：
2.9
通讯作者：
Rivest, Serge
中科院分区：
文献类型：
--
作者：
Filali, Mohammed;Lalonde, Robert;Rivest, Serge
阿尔茨海默病的特点是社会沟通缺陷，与广泛性冷漠或躁动以及社会记忆有关。为了评估6月龄雄性APPswe/PS1双基因相对于非转基因对照的社会行为，我们采用了三室试验，并结合开放场和高架迷宫探索试验。APPswe/PS1小鼠比野生型小鼠更不愿意参与社会互动，避免不熟悉的刺激小鼠，可能不是由于广义冷漠，因为在两项探索活动的测试中，突变体都是过度活跃的。这项研究揭示了APPswe/PS1老年痴呆症小鼠模型中“社交能力”降低与多动症的结合。(C) 2011爱思唯尔公司版权所有。
Alzheimer's disease is characterized by deficits in social communication, associated with generalized apathy or agitation, as well as social memory. To assess social behaviors in 6-month-old male APPswe/PS1 bigenics relative to non-transgenic controls, the 3-chamber test was used, together with open-field and elevated plus-maze tests of exploration. APPswe/PS1 mice were less willing to engage in social interaction than wild-type, avoiding an unfamiliar stimulus mouse, probably not due to generalized apathy because in both tests of exploratory activity the mutants were hyperactive. This study reveals reduced "sociability" combined with hyperactivity in an APPswe/PS1 mouse model of Alzheimer dementia. (C) 2011 Elsevier Inc. All rights reserved.