CMTM5 induces apoptosis of pancreatic cancer cells and has synergistic effects with TNF-α
CMTM5 induces apoptosis of pancreatic cancer cells and has synergistic effects with TNF-α
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DOI：
10.1016/j.bbrc.2009.06.148
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发表时间：
2009-09-11
影响因子：
3.1
通讯作者：
Han, Wenling
中科院分区：
文献类型：
--
作者：
Guo, Xiaohuan;Li, Ting;Han, Wenling
我们之前的数据表明，CKLF样MARVEL跨膜结构域成员5（CMTM5）是一种潜在的抑癌基因，但其在胰腺癌中的功能尚不清楚。在此，我们首次报道CMTM5在启动子甲基化的胰腺癌细胞系中也不存在。与正常胰腺组织相比，癌组织中CMTM5显着降低。 CMTM5-v1的恢复不仅通过激活caspase 3、8和9诱导MIA PaCa-2细胞凋亡，而且与TNF-α具有协同作用。因此，CMTM5可能在胰腺癌中发挥作用。 (C) 2009 Elsevier Inc. 保留所有结果。
Our previous data show that CKLF-like MARVEL transmembrane domain-containing member 5 (CMTM5) is a potential tumor suppressor gene, but its function ill pancreatic cancer is Unknown. Herein we first report that CMTM5 is also absent in pancreatic cancer cell lines with promoter methylation. Compared with normal pancreatic tissues, CMTM5 is significantly decreased in cancer tissues. Restoration of CMTM5-v1 not only induces MIA PaCa-2 cell apoptosis with activation of caspase 3, 8 and 9. but also has synergistic effects with TNF-alpha. Thus, CMTM5 may play a role in the pancreatic cancer. (C) 2009 Elsevier Inc. All results reserved.