Outcome of rectal cancer surgery in obese and nonobese patients: a meta-analysis.
Outcome of rectal cancer surgery in obese and nonobese patients: a meta-analysis.
复制标题
肥胖和非肥胖患者直肠癌手术的结果：荟萃分析
DOI：
10.1186/s12957-016-0775-y
复制
发表时间：
2016-01-25
影响因子：
3.2
通讯作者：
Yang H
中科院分区：
文献类型：
--
作者：
Qiu Y;Liu Q;Chen G;Wang W;Peng K;Xiao W;Yang H
研究背景肥胖症的全球流行日益严重，它对健康有着严重的负面影响，已引起全世界的关注。直肠癌手术的技术难度在肥胖患者中加剧，这可能会影响结果。高质量的相关证据有限。本荟萃分析的目的是评估肥胖和nonobese patients.MethodsThe电子数据库Pubmed，Medline，Embase，Web of Science和科克伦图书馆的直肠癌手术的结果被用来搜索的文章，评估肥胖和nonobese患者的直肠癌手术的结果。使用固定效应和随机效应模型计算汇总数据的合并总体效应量。数据呈现为比值比（OR）或加权平均差异（WMD）与95%的置信区间（CIs）。ResultsTen适当的观察性研究，确定从290篇已发表的文章。在肥胖组中，（OR 2.78; 95% CI 1.67-4.61），总体发病率（OR 1.36; 95% CI 1.25-1.47），吻合口漏（OR 3.94; 95% CI 1.88-8.24）、伤口感染（OR 2.22; 95% CI 1.47，3.36）和肺部事件（OR 2.10; 95% CI 1.18，3.74）均显着增加。对于病理结果，收获的淋巴结和阳性边缘的数量没有统计学差异，注意到两组之间。ConclusionsBased上的荟萃分析，肥胖增加直肠癌手术的转换率和术后发病率，但不影响病理结果。
BackgroundThe escalating global epidemic of obesity is of worldwide concern because of its association with serious negative effects on health. The technical difficulty of rectal cancer surgery is exacerbated in obese patients, which may compromise outcomes. High-quality, relevant evidence is limited. This meta-analysis aims to assess the outcomes of rectal cancer surgery in obese and nonobese patients.MethodsThe electronic databases Pubmed, Medline, Embase, Web of Science, and the Cochrane Library were used to search for articles that evaluated the outcomes of rectal cancer surgery in obese and nonobese patients. Fixed-effects and random-effects models were used to calculate the combined overall effect sizes of pooled data. Data are presented as odds ratios (OR) or weighted mean differences (WMD) with 95 % confidence intervals (CIs).ResultsTen appropriate observational studies were identified from 290 published articles. In the obese group, conversion rates (OR 2.78; 95 % CI 1.67–4.61), overall morbidity (OR 1.36; 95 % CI 1.25–1.47), anastomotic leak (OR 3.94; 95 % CI 1.88–8.24), wound infection (OR 2.22; 95 % CI 1.47, 3.36), and pulmonary events (OR 2.10; 95 % CI 1.18, 3.74) were all significantly increased. For pathological results, no statistical differences in the number of harvested lymph nodes and the positive margin were noted between the two groups.ConclusionsBased on a meta-analysis, obesity increases the conversion rate and postoperative morbidity of rectal cancer surgery but does not influence pathological results.