DUAL-ACTION PENEMS AND CARBAPENEMS
DUAL-ACTION PENEMS AND CARBAPENEMS
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DOI：
10.1021/jm00088a019
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发表时间：
1992-05-15
影响因子：
7.3
通讯作者：
WEI, CC
中科院分区：
文献类型：
--
作者：
CORRAZ, AJ;DAX, SL;WEI, CC
合成了青霉烯类和碳青霉烯类2‘-位通过酯或氨基甲酸酯基团连接到喹诺酮类药物上的两种新型双作用抗菌剂。观察到这两类化合物都有很强的广谱抗菌活性，表明这是一种双重作用模式。
Two new series of dual-action antibacterial agents were synthesized in which penems and carbapenems were linked at the 2'-position to quinolones through either an ester or a carbamate moiety. Potent, broad-spectrum antibacterial activity was observed for both classes of compounds, indicative of a dual-mode of action.