PEPTIDES AND THE BLOOD-BRAIN-BARRIER - THE STATUS OF OUR UNDERSTANDING
PEPTIDES AND THE BLOOD-BRAIN-BARRIER - THE STATUS OF OUR UNDERSTANDING
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DOI：
10.1111/j.1749-6632.1994.tb19810.x
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发表时间：
1994-01-01
期刊：
影响因子：
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通讯作者：
BEGLEY, DJ
中科院分区：
文献类型：
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作者：
BEGLEY, DJ
在这篇有限的综述中，只能强调一些更重要的多肽与血脑屏障的相互作用。近年来文献复习较多，主要综述文献包括。当然，一个突出的主要问题是阐明中枢活性多肽产生作用的确切机制(S)。毫无疑问，外周给药的多肽能够改变中枢神经的活动；对于数量迅速增加的多肽，可以证明是由大脑内皮细胞提取的。对于这些多肽中的一些，提取涉及高度特异的转运蛋白。目前尚不清楚的是，多肽内化到内皮细胞是跨细胞作用的第一步，最终是完整多肽或活性片段的胞外排泄到脑细胞外液中，或者它们是否通过不同的途径进入脑胞外液。另一方面，如果中枢作用的机制是通过脑室周围器官，则可能不需要进入脑细胞外液。显然，对于不同的多肽，作用的路线和机制将不同，未来的注意力应该集中在产生特定多肽的中枢作用的准确机制上。
In this limited review, it has only been possible to highlight some of the more significant interactions of peptides with the blood-brain barrier. The literature has been reviewed extensively in recent years, and the major reviews are included in the references. Certainly one of the major outstanding problems is an elucidation of the precise mechanism (s) by which centrally active peptides produce their effects. Without question peripherally administered peptides are able to modify central nervous activity; and for a rapidly growing number of peptides, an extraction by the cerebral endothelial cells can be demonstrated. For some of these peptides, the extraction involves highly specific transporters. What is far less clear is whether this internalization of peptide into the endothelial cells is the first step in a process of transcytosis, with an eventual abluminal exocytosis into brain extracellular fluid of the intact peptide, or an active fragment or whether their entry into brain extracellular fluid is via a different route. If, on the other hand, the mechanism of central action is via the circumventricular organs, a general entry into brain extracellular fluid may not be required. Clearly for different peptides the route and mechanism of action will differ and future attention should be focused on the precise mechanisms producing the central effects of defined peptides.