Catalytic enantioselective synthesis of chiral spirocyclic 1,3-diketones via organo-cation catalysis
Catalytic enantioselective synthesis of chiral spirocyclic 1,3-diketones via organo-cation catalysis
复制标题
有机阳离子催化对映选择性合成手性螺环1,3-二酮
DOI：
10.1039/d1cc05205e
复制
发表时间：
2021
影响因子：
4.9
通讯作者：
Yong-Qiang Tu
中科院分区：
文献类型：
--
作者：
Xiao-Yan Zhang;Ya-Ping Shao;Bao-Kuan Guo;Kun Zhang;Fu-Min Zhang;Xiao-Ming Zhang;Yong-Qiang Tu
提出了 SPA-溴化三唑催化的烯醇内酯的跨环 C-酰化反应。该方法能够以中等到高产率和对映选择性方便地获得一系列对映体富集的螺环 1,3-二酮，并且在烯醇内酯方面具有广泛的底物范围。这种三唑盐催化剂的催化能力也在这种对映选择性转化中得到了证明，这可以激发其进一步的应用。
An SPA-triazolium bromide-catalyzed transannular C-acylation of enol lactones is presented. This methodology provides convenient access to a range of enantioenriched spirocyclic 1,3-diketones in moderate to high yields and enantioselectivities and features a broad substrate scope in terms of enol lactones. The catalytic capability of this triazolium salt catalyst is also demonstrated in this enantioselective transformation, which could inspire its further application.