PREVALENCE OF ALZHEIMERS-DISEASE IN A COMMUNITY POPULATION OF OLDER PERSONS - HIGHER THAN PREVIOUSLY REPORTED
PREVALENCE OF ALZHEIMERS-DISEASE IN A COMMUNITY POPULATION OF OLDER PERSONS - HIGHER THAN PREVIOUSLY REPORTED
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DOI：
10.1001/jama.262.18.2551
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发表时间：
1989-11-10
影响因子：
120.7
通讯作者：
TAYLOR, JO
中科院分区：
文献类型：
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作者：
EVANS, DA;FUNKENSTEIN, H;TAYLOR, JO
临床诊断为阿尔茨海默病的S病和其他痴呆症在一个地理上定义的美国社区进行了评估。在3623人(占所有65岁以上社区居民的80.8%)中，分层抽样467人进行了神经学、神经心理学和实验室检查。从接受临床评估的样本中计算社区人群阿尔茨海默病S病的患病率。在65岁以上的人群中，估计有10.3%(95%的可信区间，8.1%和12.5%)可能患有阿尔茨海默病的S病。这一患病率与年龄密切相关。在65-74岁人群中，3.0%(95%可信区间，0.8和5.2)可能患有阿尔茨海默病S病，而在75-84岁人群中，这一比例为18.7%(95%可信区间，13.2和24.2)，在85岁以上人群中为47.2%(95%可信区间，37.0和63.2)。其他精神错乱的情况并不常见。在中度或重度认知障碍的社区居民中，84.1%的人曾将临床诊断为阿尔茨海默病的唯一可能诊断为S病。这些数据表明，临床诊断为阿尔茨海默病的S病是一种常见疾病，随着人口寿命的延长，其对公共健康的影响将继续增加。
Clinically diagnosed Alzheimer''s disease and other dementing illnesses were assessed in a georaphically defined US community. Of 3623 persons (80.8% of all community residents over 65 years of age) who had brief memory testing in their homes, a stratified sample of 467 persons underwent neurological, neuropsychological, and labortory examination. Prevalence rates of Alzheimer''s disease were calculated for the community population from the sample undergoing clinical evaluation. Of those over the age of 65 years, and estimated 10.3% (95% confidence limits, 8.1% and 12.5%) had probable Alzheimer''s disease. This prevalence rate was strongly associated with age. Of those 65 to 74 years old, 3.0% (95% confidence limits, 0.8 and 5.2) had probable Alzheimer''s disease, compared with 18.7% (95% confidence limits, 13.2 and 24.2) of those 75 to 84 years old and 47.2% (95% confidence limits, 37.0 and 63.2) of those over 85 years. Other dementing conditions were uncommon. Of community residents with moderate or severe cognitive impairment, 84.1% had clinically diagnosed Alzheimer''s disease as the only probable diagnosis. These data suggest that clinically diagnosed Alzheimer''s disease is a common condition and that its public health impact will continue to increase with increasing longevity of the population.