Biochemical composition of the epidermal-dermal junction and other basement membrane.
Biochemical composition of the epidermal-dermal junction and other basement membrane.
复制标题
表皮-真皮交界处和其他基底膜的生化成分。
DOI：
10.1111/1523-1747.ep12497841
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Briggaman,RA
中科院分区：
文献类型：
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作者：
Briggaman,RA
在过去的几年中，我们对表皮-真皮交界处的生化组成和影响该区域的许多皮肤病中病理反应的超微结构位置的认识大大增加。在本文中，我们的目的是回顾这些领域的当前信息。表皮-真皮交界处之前已进行过综述，读者可参考这些文献，以获得对该主题更一般和全面的综述[1-5]。首先，对表皮-真皮交界处的超微结构形态进行简要回顾，以便与后续研究联系起来。表皮-真皮交界处比光镜观察到的表皮和真皮之间的简单线性“基底膜区”更复杂，超微结构更高度组织化。三种不同的表皮细胞类型，即基底角质形成细胞、黑素细胞和默克尔细胞，构成表皮-真皮交界处的一部分，每种细胞类型在交界处呈现稍微不同的外观。基底角质形成细胞形成绝大多数的交界区，将是唯一的细胞在这里考虑。为了方便起见，基底角质形成细胞和真皮之间的表皮-真皮连接处从表皮向真皮可分为4个小块（图）。这些ru· e：具有特殊附着结构的基底细胞质膜，半桥粒;透明层;基底层;和亚基底层纤维区。基底角质形成细胞的质膜是三层结构，厚度约为7-9纳米（nm）。细胞质膜上频繁地出现电子密集的增厚物。这些结构被称为半桥粒，如图所示。半桥粒是由电子致密区，附着斑，这是目前的细胞质侧
During the last several yeaTs, our knowledge of the biochemical composition of the epidermal-dermal junction and the ultrastructural location of the pathologic reaction in numerous skin diseases that affect this area has increased greatly. In this paper, our purpose is to review current information in these areas. The epidermal-dermal junction has been reviewed previously and the reader is referred to these somces for a more general and comprehensive review of the subject [1-5). First, a brief review of the ultrastructural morphology of the epidermal-dermal junction is necessary to relate the subsequent studies. The epidermal-dermal junction is more complex and more highly organized ultrastructurally than the simple linear" basement membrane zone" between epidermis and dermis noted by light microscopy. Three different epidermal cell types, basal keratinocyte, melanocyte, and Merkel cell, comprise a portion of the epidermal-dermal junction with each cell type presenting a somewhat different appearance at the junction. Basal keratinocytes form the vast majority of the junction zone and will be the only cell considered here. The epidermal-dermal junction between basal keratinocytes and dermis can be divided, for convenience, into 4 ru· eas proceeding from epidermis toward the dermis (Figure). These ru· e: The basal cell plasma membrane with its special attachment structures, hemidesmosomes; lamina Iucida; the basal lamina; and a sub-basal lamina fibrous zone.The plasma membrane of basal keratinocytes is a trilaminar structure measuring approximately 7-9 nanometers (nm) in thickness. Electron dense thickenings stud the plasma membrane at frequent intervals. These structures are termed hemidesmosomes and are diagramatically presented in the Figme. The hemidesmosome is composed of an electron dense area, the attachment plaque, that is present on the cytoplasmic side