Activation of different anterior cingulate foci in association with hypothesis testing and response selection
Activation of different anterior cingulate foci in association with hypothesis testing and response selection
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DOI：
10.1006/nimg.1998.0344
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发表时间：
1998-07-01
期刊：
影响因子：
5.7
通讯作者：
Dolan, RJ
中科院分区：
文献类型：
--
作者：
Elliott, R;Dolan, RJ
许多日常行为都隐含地受到对世界的假设的指导，这些假设是根据不断变化的环境进行监控和更新的。将这些假设转化为行为的过程通常涉及执行选择，通常基于不完全指定的信息。本研究旨在对这些过程进行建模，以确定假设检验的神经基质，特别是这些过程是如何被做出选择的要求所调节的。我们使用正电子发射断层扫描来研究6名右撇子志愿者，他们正在执行一项不可解的假设检验任务，在这项任务中，受试者试图确定一个规则，决定两个黑白棋盘刺激中哪一个是正确的。该任务与知觉运动要求匹配的对照任务进行比较，但不涉及假设检验。这两项任务都有或没有做出选择的要求。与假设检验相关的激活结构包括小脑、左侧前扣带、右侧楔前叶、右侧丘脑和左侧额下回。选择反应的要求与左侧前扣带和右侧外侧眶额皮质的激活有关。在前扣带区观察到与假设检验相关的激活的显著调节，该区域也通过做出选择而激活。这些发现在复杂的“执行”任务的神经基质方面进行了讨论。我们认为，这些任务的精确认知参数，特别是在实际行为中实施决策的要求，对于确定相关的神经反应至关重要。(C) 1998学术出版社。
Much everyday behavior is implicitly guided by hypotheses about the world which are monitored and updated in the light of changing circumstances. The process of translating these hypotheses into behavior typically involves implementing choices, often based on incompletely specified information. The present study aimed at modeling these processes to determine the neural substrates of hypothesis testing and, in particular, how these are modulated by the requirement to make choices. We used positron emission tomography to study six right-handed volunteers performing an insoluble hypothesis testing task in which subjects attempted to identify a rule determining which of two black and white checkerboard stimuli was correct. This task was compared with a control task matched for perceptuomotor requirements, but involving no hypothesis testing. Both tasks were performed with or without a requirement to make a choice. Structures activated in association with hypothesis testing included the cerebellum, left anterior cingulate, right precuneus, right thalamus, and left inferior frontal gyrus. The requirement to choose a response was associated with activation of the left anterior cingulate and right lateral orbitofrontal cortex. A significant modulation of activation associated with hypothesis testing was observed in the anterior cingulate region that was also activated by making a choice. These findings are discussed in terms of the neural substrates of complex "executive" tasks. We argue that the precise cognitive parameters of such tasks, and specifically the requirement to implement decisions in actual behavior, are critical in determining the associated neural response. (C) 1998 Academic Press.