The significance of aberrant crypt foci in understanding the pathogenesis of colon cancer
The significance of aberrant crypt foci in understanding the pathogenesis of colon cancer
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DOI：
10.1016/s0378-4274(99)00261-1
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发表时间：
2000-03-15
影响因子：
3.5
通讯作者：
Good, CK
中科院分区：
文献类型：
--
作者：
Bird, RP;Good, CK
动物模型提供了一个独特的机会来研究疾病过程的生物学，并测试将环境因素与结肠癌的病因学和预防联系起来的假设。癌症预防的概念是延缓、消退或消除癌前病变。为了实现这一概念，重要的是识别和列举各种生长尺寸的肿瘤前病变。通过鉴定用致癌物处理的啮齿动物结肠中的异常隐窝病灶（ACF），可以对结肠癌前阶段进行研究。 ACF 的生长、形态和分子特征支持 ACF 是推定的癌前病变的论点。 ACF 系统广泛用于鉴定结肠癌发生的调节剂。在癌症研究中使用的各种终点中，ACF 是唯一提供定量方法来评估疾病过程以及受癌症预防或促进剂影响的潜在细胞和分子事件的终点。许多饮食成分根据其改变肿瘤结果的能力被归类为肿瘤促进剂或抑制剂。它们是否影响极早期或晚期癌前病变的生长尚不清楚，可以通过使用 ACF 系统进行探索。这些信息将有助于更好地了解癌症发病机制，并将导致针对高危人群和普通人群制定不同的癌症预防策略。 (C) 2000 Elsevier Science Ireland Ltd. 保留所有权利。
Animal models provide a unique opportunity to study the biology of the disease process, and to test hypotheses linking environmental factors in the etiology and prevention of colon cancer. The concept of cancer prevention is to retard, regress or eliminate precancerous lesions. To actuate this concept, it is important to identify and enumerate preneoplastic lesions of various growth dimensions. The study of the precancerous stages in the colon is possible by the identification of aberrant crypt foci (ACF) in rodent colons treated with a carcinogen. The growth, morphological and molecular features of ACF support the contention that ACF are putative preneoplastic lesions. The ACF system is used extensively to identify modulators of colon carcinogenesis. Among the various endpoints being used in cancer research, ACF are the only endpoints which provides a quantitative approach to assess the disease process and the underlying cellular and molecular events as affected by cancer preventive or promoting agents. Many dietary components have been classified as tumor promoters or inhibitors based on their ability to change the tumor outcome. Whether they affect the growth of very early or advanced preneoplastic lesions is not known and can be explored by using ACF system. This information will provide a better understanding of cancer pathogenesis and will lead to the development of different cancer preventive strategies for high-risk individuals and the general population. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.