Immunotherapy and stereotactic ablative radiotherapy (ISABR): a curative approach?
Immunotherapy and stereotactic ablative radiotherapy (ISABR): a curative approach?
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DOI：
10.1038/nrclinonc.2016.30
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发表时间：
2016-08
期刊：
影响因子：
--
通讯作者：
Chang JY
中科院分区：
文献类型：
--
作者：
Bernstein MB;Krishnan S;Hodge JW;Chang JY
Conventional radiotherapy, in addition to its well-established tumoricidal effects, can also activate the host immune system. Radiation therapy modulates tumour phenotypes, enhances antigen presentation and tumour immunogenicity, increases production of cytokines and alters the tumour microenvironment, enabling destruction of the tumour by the immune system. Investigating the combination of radiotherapy with immunotherapeutic agents, which also promote the host antitumour immune response is, therefore, a logical progression. As the spectrum of clinical use of stereotactic radiotherapy continues to broaden, the question arose as to whether the ablative radiation doses used also stimulate immune responses and, if so, whether we can amplify these effects by combining immunotherapy and stereotactic ablative radiotherapy (SABR). In this Perspectives article, we explore the preclinical and clinical evidence supporting activation of the immune system following SABR. We then examine studies that provide data on the effectiveness of combining these two techniques — immunotherapy and SABR — in an approach that we have termed ‘ISABR.’ Lastly, we provide general guiding principles for the development of future clinical trials to investigate the efficacy of ISABR in the hope of generating further interest in these exciting developments.
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DOI：
10.1038/nrg3931
发表时间：
2015-06
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
Henn BM;Botigué LR;Bustamante CD;Clark AG;Gravel S
通讯作者：
Gravel S
影响因子：
3.7
作者：
Imaizumi N;Monnier Y;Hegi M;Mirimanoff RO;Rüegg C
通讯作者：
Rüegg C
影响因子：
51.1
作者：
Chang, Joe Y.;Senan, Suresh;Paul, Marinus A.;Mehran, Reza J.;Louie, Alexander V.;Balter, Peter;Groen, Harry J. M.;McRae, Stephen E.;Widder, Joachim;Feng, Lei;van den Borne, Ben E. E. M.;Munsell, Mark F.;Hurkmans, Coen;Berry, Donald A.;van Werkhoven, Erik;Kresl, John J.;Dingemans, Anne-Marie;Dawood, Omar;Haasbeek, Cornelis J. A.;Carpenter, Larry S.;De Jaeger, Katrien;Komaki, Ritsuko;Slotman, Ben J.;Smit, Egbert F.;Roth, Jack A.
通讯作者：
Roth, Jack A.
DOI：
10.1158/1078-0432.ccr-09-0265
发表时间：
2009-09-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Dewan MZ;Galloway AE;Kawashima N;Dewyngaert JK;Babb JS;Formenti SC;Demaria S
通讯作者：
Demaria S
影响因子：
3.5
作者：
Crittenden M;Kohrt H;Levy R;Jones J;Camphausen K;Dicker A;Demaria S;Formenti S
通讯作者：
Formenti S