Spatial mapping of the percentage cellularity in human bone marrow using magnetic resonance imaging.
Spatial mapping of the percentage cellularity in human bone marrow using magnetic resonance imaging.
复制标题
使用磁共振成像对人骨髓细胞构成百分比进行空间绘图。
DOI：
10.1118/1.597796
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发表时间：
1996
期刊：
影响因子：
3.8
通讯作者：
Koutcher,JA
中科院分区：
文献类型：
--
作者：
Ballon,D;Jakubowski,AA;Graham,MC;Schneider,E;Koutcher,JA
本文介绍了一种非侵入性测定人骨髓细胞百分比空间分布的方法。使用两种磁共振成像技术对12名受试者进行了研究：（1）频率选择性预饱和快速自旋回波成像，以及（2）三点化学位移成像。将数据与使用先前验证的受激回波光谱法获得的结果进行比较。本研究的结果表明，如果在整个感兴趣区域实现高质量的水或脂质抑制，则可以使用磁共振成像技术测量骨髓中的细胞百分比。由于该方法适用于任何解剖位置的骨髓，它可能被证明是有用的剂量计算过程中和后的内部或外部束放射治疗。
A noninvasive assay for the spatial distribution of the percentage cellularity in human bone marrow is presented. Twelve individuals were studied using two magnetic resonance imaging techniques: (1) fast spin echo imaging with frequency selective presaturation, and (2) three‐point chemical shift imaging. The data were compared to results obtained using a previously validated stimulated echo spectroscopic method. The results of this study demonstrate that a measure of the percentage cellularity in bone marrow is possible using magnetic resonance imaging techniques provided that high‐quality water or lipid suppression is achieved across the region of interest. Since the method is applicable to bone marrow at any anatomic location, it may prove useful in dosimetric calculations during and after a course of internal or external beam radiotherapy.