Effect of prostaglandin E1 on cerebral circulatory disturbances following subarachnoid haemorrage in man
Effect of prostaglandin E1 on cerebral circulatory disturbances following subarachnoid haemorrage in man
复制标题
前列腺素E1对男性蛛网膜下腔出血脑循环障碍的影响
DOI：
10.1007/bf00344804
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发表时间：
1972
期刊：
影响因子：
2.8
通讯作者：
L. Carlson
中科院分区：
文献类型：
--
作者：
L. Steiner;D. Forster;U. Bergvall;L. Carlson
PIP：观察前列腺素E_1(PGE_1)对蛛网膜下腔出血后脑血管痉挛的临床疗效。PGE1的剂量从0.000002ug/kg/min到0.03ug/kg/min不等，用于3名男性和3名女性患者的颈内动脉注射，这些患者大多因动脉动脉瘤而患有蛛网膜下腔出血。如果需要重复注射，则使用10倍以上的剂量浓度。测量动脉内径、循环时间和脑血流量。监测血压、呼吸和心电图的变化。未观察到明确的解痉剂作用。未记录重大不良反应。其中5例患者的临床症状在输注PGE1后没有改变。第6例在注射后几小时后短暂好转。研究中的剂量很小。问题仍然是，PGE1的血管活性作用是由于直接抑制血管平滑肌上的儿茶酚胺作用，还是由于PGE1的无关血管扩张作用。
PIP: Clinical research was carried out to determine the efficiency of PGE1 (prostaglandin E1) as a spasmolytic agent on cerebral vasospasm after subarachnoid bleeding. PGE1, ranging in dosage from .000002 ug/kg/min-.03 ug/kg/min., was injected into the internal carotid artery of 3 male and 3 female subjects suffering from subarachnoid bleeding due, in most of the cases, to arterial aneurysm. A 10-fold higher dosage concentration was used if repeat injection was required. Arterial diameter, circulation time and cerebral blood flow were measured. Blood pressure, respiration, and electrocardiographic changes were monitored. No definite spasmolytic effects were observed. No major adverse reactions were recorded. The clinical condition of 5 of the subjects was not changed after PGE1 infusion. The 6th case improved briefly after a few hours postinjection. Dosages in the study were small. The question remains as to whether the vasoactive effect of PGE1 is due to direct inhibition of the catecholamine effect on vascular smooth muscle or due to an unrelated vasodilator effect of PGE1.