Pathogenesis of Type 2 Epithelial to Mesenchymal Transition (EMT) in Renal and Hepatic Fibrosis.
Pathogenesis of Type 2 Epithelial to Mesenchymal Transition (EMT) in Renal and Hepatic Fibrosis.
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DOI：
10.3390/jcm5010004
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发表时间：
2015-12-30
影响因子：
3.9
通讯作者：
Yamate J
中科院分区：
文献类型：
--
作者：
Tennakoon AH;Izawa T;Kuwamura M;Yamate J
上皮间质转化（EMT），特别是2型EMT，在进行性肾纤维化和肝纤维化中很重要。在此过程中，不完全再生的肾上皮细胞失去其上皮特征，并获得肌成纤维细胞的迁移间充质质量。在肝纤维化（重要的是，肝硬化）中，该过程也发生在受损的肝细胞和肝祖细胞（HPC）以及与胆管反应相关的胆汁上皮细胞中。有趣的是，胆管反应部分地有助于HPC的肝癌发生，并且进一步地，损伤后再生的胆管细胞可能通过间充质向上皮细胞的转化而源自肝星状细胞，这是2型EMT的相反现象。本文就2型EMT的可能发病机制及其在肾纤维化和肝纤维化中的差异作一综述。
Epithelial to mesenchymal transition (EMT), particularly, type 2 EMT, is important in progressive renal and hepatic fibrosis. In this process, incompletely regenerated renal epithelia lose their epithelial characteristics and gain migratory mesenchymal qualities as myofibroblasts. In hepatic fibrosis (importantly, cirrhosis), the process also occurs in injured hepatocytes and hepatic progenitor cells (HPCs), as well as ductular reaction-related bile epithelia. Interestingly, the ductular reaction contributes partly to hepatocarcinogenesis of HPCs, and further, regenerating cholangiocytes after injury may be derived from hepatic stellate cells via mesenchymal to epithelia transition, a reverse phenomenon of type 2 EMT. Possible pathogenesis of type 2 EMT and its differences between renal and hepatic fibrosis are reviewed based on our experimental data.