Pharmacometrics of Stilbenes: Seguing Towards the Clinic
Pharmacometrics of Stilbenes: Seguing Towards the Clinic
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DOI：
10.2174/157488406775268246
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发表时间：
2006-01-01
影响因子：
3.2
通讯作者：
Davies, Neal M.
中科院分区：
文献类型：
--
作者：
Roupe, Kathryn A.;Remsberg, Connie M.;Davies, Neal M.
二苯乙烯是一种小分子(类似于200-300克/摩尔)的天然化合物，广泛存在于各种植物来源、芳香疗法产品和膳食补充剂中。这些分子是通过苯丙烷途径合成的，在结构上与雌激素有一些相似之处。在受到环境威胁时，植物寄主激活苯丙烷途径，产生二苯乙烯结构并随后分泌。二苯乙烯类化合物作为天然保护剂来保护植物免受病毒和微生物的攻击，过量的紫外线照射和疾病。白藜芦醇是一种二苯乙烯类化合物，已被广泛研究，并被证明具有强大的抗癌、抗炎和抗氧化活性。白藜芦醇主要存在于葡萄皮中，是由葡萄属植物在受到真菌感染或其他环境压力时合成的。大量研究表明，白藜芦醇是对抗多种癌症和疾病的有吸引力的候选者，这激发了人们对确定其他结构相似的二苯乙烯类化合物的抗病能力的兴趣。本文综述了四种结构相似的二苯乙烯类化合物，即白藜芦醇、松脂素、雷公藤素和二苯乙烯类化合物，并详细介绍了目前的一些药物研究情况和它们潜在的临床应用。
Stilbenes are small molecular weight (similar to 200-300 g/mol), naturally occurring compounds and are found in a wide range of plant sources, aromatherapy products, and dietary supplements. These molecules are synthesized via the phenylpropanoid pathway and share some structural similarities to estrogen. Upon environmental threat, the plant host activates the phenylpropanoid pathway and stilbene structures are produced and subsequently secreted. Stilbenes act as natural protective agents to defend the plant against viral and microbial attack, excessive ultraviolet exposure, and disease. One stilbene, resveratrol, has been extensively studied and has been shown to possess potent anti-cancer, antiinflammatory and anti-oxidant activities. Found primarily in the skins of grapes, resveratrol is synthesized by Vitis vinifera grapevines in response to fungal infection or other environmental stressors. Considerable research showing resveratrol to be an attractive candidate in combating a wide variety of cancers and diseases has fueled interest in determining the disease-fighting capabilities of other structurally similar stilbene compounds. The purpose of this review is to describe four such structurally similar stilbene compounds, piceatannol, pinosylvin, rhapontigenin, and pterostilbene and detail some current pharmaceutical research and highlight their potential clinical applications.