Developmental 'awakening' of primary motor cortex to the sensory consequences of movement
Developmental 'awakening' of primary motor cortex to the sensory consequences of movement
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DOI：
10.7554/elife.41841
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发表时间：
2018-12-21
期刊：
影响因子：
7.7
通讯作者：
Blumberg, Mark S.
中科院分区：
文献类型：
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作者：
Dooley, James C.;Blumberg, Mark S.
在初级运动皮层 (M1) 发育其运动功能之前，它的功能类似于体感区域。在这里，通过记录出生后第 8-12 天 (P) 的大鼠前肢 M1 神经元的表现，我们证明了其感觉反应的快速转变。在 P8-10，M1 神经元对来自睡眠相关的前肢抽搐的反馈做出强烈反应，但相同的神经元对与唤醒相关的运动没有反应。到了 P12，M1 神经元突然对唤醒运动做出反应，这是由于打开外部楔状核中的感觉门而产生的转变。同样在 P12，较少的 M1 神经元对单个抽搐作出反应，但在 P8 观察到的抽搐相关反馈的完整补充通过局部去抑制被揭示。最后，到 P12，M1 感觉反应起源于丘脑接受层深层，而不是初级体感皮层。这些发现表明，M1 最初建立了一个感觉框架，随后在运动控制中发挥了作用。
Before primary motor cortex (M1) develops its motor functions, it functions like a somatosensory area. Here, by recording from neurons in the forelimb representation of M1 in postnatal day (P) 8-12 rats, we demonstrate a rapid shift in its sensory responses. At P8-10, M1 neurons respond overwhelmingly to feedback from sleep-related twitches of the forelimb, but the same neurons do not respond to wake-related movements. By P12, M1 neurons suddenly respond to wake movements, a transition that results from opening the sensory gate in the external cuneate nucleus. Also at P12, fewer M1 neurons respond to individual twitches, but the full complement of twitch-related feedback observed at P8 is unmasked through local disinhibition. Finally, through P12, M1 sensory responses originate in the deep thalamorecipient layers, not primary somatosensory cortex. These findings demonstrate that M1 initially establishes a sensory framework upon which its later-emerging role in motor control is built.