Polyunsaturated fatty acids and inflammation
Polyunsaturated fatty acids and inflammation
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DOI：
10.1016/j.plefa.2006.05.012
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发表时间：
2006-09-01
影响因子：
3
通讯作者：
Calder, Philip C.
中科院分区：
文献类型：
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作者：
Calder, Philip C.
n-6多不饱和脂肪酸花生四烯酸产生类二十烷酸类介体家族（类花生四烯酸、血栓烷、白三烯和相关代谢物）。它们本身具有炎症作用，并且还调节包括炎性细胞因子在内的其他介质的产生。长链n-3多不饱和脂肪酸的消耗减少了细胞膜中花生四烯酸的量，因此可用于类花生酸的生产。因此，n-3多不饱和脂肪酸减少花生四烯酸衍生的类二十烷酸的产生。这些脂肪酸还减少经典炎症细胞因子肿瘤坏死因子、白细胞介素-1和白细胞介素-6的产生，以及参与白细胞和内皮细胞之间炎症相互作用的粘附分子的表达。后者的作用可能通过类花生酸非依赖性机制发生，包括调节参与炎症过程的转录因子的活化。长链n-3脂肪酸诱导效应的抑制作用可能在具有急性或慢性炎症组分的病症中具有治疗用途。(c)2006爱思唯尔有限公司版权所有。
The n-6 polyunsaturated fatty acid arachidonic acid gives rise to the eicosanoid family of mediators (prostaglandins, thromboxanes, leukotrienes and related metabolites). These have inflammatory actions in their own right and also regulate the production of other mediators including inflammatory cytokines. Consumption of long chain n-3 polyunsaturated fatty acids decreases the amount of arachidonic acid in cell membranes and so available for eicosanoid production. Thus, n-3 polyunsaturated fatty acids decrease production of arachidonic acid-derived eicosanoids. These fatty acids also decrease the production of the classic inflammatory cytokines tumour necrosis factor, interleukin-1, and interleukin-6 and the expression of adhesion molecules involved in inflammatory interactions between leukocytes and endothelial cells. These latter effects may occur by eicosanoid-independent mechanisms including modulation of the activation of transcription factors involved in inflammatory processes. The antiinflammatory actions of long chain n-3 fatty acid-induced effects may be of therapeutic use in conditions with an acute or chronic inflammatory component. (c) 2006 Elsevier Ltd. All rights reserved.