THE VENTILATORY CO2 SENSITIVITIES FROM READ REBREATHING METHOD AND THE STEADY-STATE METHOD ARE NOT EQUAL IN MAN
THE VENTILATORY CO2 SENSITIVITIES FROM READ REBREATHING METHOD AND THE STEADY-STATE METHOD ARE NOT EQUAL IN MAN
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DOI：
10.1113/jphysiol.1989.sp017578
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发表时间：
1989-04-01
影响因子：
5.5
通讯作者：
OLIEVIER, ICW
中科院分区：
文献类型：
--
作者：
BERKENBOSCH, A;BOVILL, JG;OLIEVIER, ICW
比较了Read再呼吸法和稳态呼吸法在高氧期间对潮末二氧化碳张力变化的通气反应。在10名年轻的男性受试者中，在13个不同的早晨时段进行了40次成功的再呼吸和13次稳态实验。在所有受试者中，用再呼吸法获得的通气CO2敏感性（Sr）明显大于稳态CO2敏感性（Ss）。Sr/Ss比值为1.40 ~ 2.59，平均值为1.85。我们认为，这些结果可以通过考虑在再呼吸和稳定状态时脑血流量变化对动脉二氧化碳张力增加的影响来解释。我们得出结论，用Read的再呼吸法得到的CO2灵敏度一般不能代表稳态CO2灵敏度。
The ventilatory response to changes in end-tidal carbon dioxide tension during hyperoxia, obtained with Read''s rebreathing method and a steady-state technique, were compared. In ten young male subjects, forty successful rebreathing and thirteen steady-state experiments were performed on thirteen different morning sessions. In all subjects the ventilatory CO2-sensitivities obtained with the rebreathing method (Sr) were appreciably larger than the steady-state CO2 sensitivities (Ss). The ratio Sr/Ss ranged from 1.40 to 2.59 with a mean value of 1.85. We argue that these results can be explained by considering the effect of changes in cerebral blood flow upon increasing the arterial CO2 tension during rebreathing and the steady state. We conclude that in general the CO2 sensitivity obtained with Read''s rebreathing method does not represent the steady-state CO2 sensitivity.