SYNTHESIS OF AN ARYLHYDROXYTETRONIMIDE AND OF 3-HYDROXY-4(1H)-QUINOLONE DERIVATIVES
SYNTHESIS OF AN ARYLHYDROXYTETRONIMIDE AND OF 3-HYDROXY-4(1H)-QUINOLONE DERIVATIVES
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DOI：
10.1071/ch9740537
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发表时间：
1974-01-01
影响因子：
1.1
通讯作者：
EASTWOOD, FW
中科院分区：
文献类型：
--
作者：
EVANS, DJ;EASTWOOD, FW
邻-（n-甲基甲氨基）苯甲醛与亚硫酸乙二醛和氰化钠在碱性溶液中反应生成2-亚胺-5-[T-（n-甲基甲氨基）苯基]-2,5-二氢呋喃-3,4-二醇。在相同的反应条件下，邻氨基和邻n -甲氨基苯甲醛分别生成3-羟基-4(1H)-喹诺酮（喹啉-3,4-二醇）和3-羟基-1-甲基-4(1H)-喹诺酮。
o-(N-Methy1formamido)benzaldehyde reacted with glyoxal bisulphite and sodium cyanide in alkaline solution to yield 2-imino-5-[T-(N-methylformamido)phenyl]-2,5-dihydrofuran-3,4-diol. Under the same reaction conditions o-amino- and o-N-methylamino-benzaldehyde yielded 3-hydroxy-4(1H)- quinolone (quinoline-3,4-diol) and 3-hydroxy-1-methyl-4(1H)-quinolone respectively.