Transcriptional modulation of foreign gene expression in engineered somatic tissues
Transcriptional modulation of foreign gene expression in engineered somatic tissues
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DOI：
10.1023/a:1007480419685
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发表时间：
1998-03-01
影响因子：
6.1
通讯作者：
Heard, JM
中科院分区：
文献类型：
--
作者：
Bohl, D;Heard, JM
作为基因治疗候选者的许多疾病需要控制治疗性基因表达水平以确保生物功效并防止毒性作用。已经描述了允许在哺乳动物细胞中通过人工嵌合反式激活因子进行转录调节的各种系统。本文介绍了这些不同的系统，并讨论了他们的兴趣基因治疗。
Many diseases that are candidates for gene therapy require that the therapeutic gene expression level be controlled to ensure biological efficacy and to prevent toxic effects. Various systems have been described that allow transcriptional regulation by artificial chimeric transactivators in mammalian cells. This paper describes these various systems and discusses their interests for gene therapy.