Heterogeneity in the prevalence of risk factors for cardiovascular disease and type 2 diabetes mellitus in obese individuals - Effect of differences in insulin sensitivity
Heterogeneity in the prevalence of risk factors for cardiovascular disease and type 2 diabetes mellitus in obese individuals - Effect of differences in insulin sensitivity
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DOI：
10.1001/archinte.167.7.642
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发表时间：
2007-04-09
影响因子：
--
通讯作者：
Reaven, Gerald
中科院分区：
文献类型：
--
作者：
McLaughlin, Tracey;Abbasi, Fahim;Reaven, Gerald
背景资料：在研究肥胖对发病率和死亡率的影响时，没有强调中度肥胖个体存在代谢异常的实质异质性的可能性。我们测试的假设，即2型糖尿病和心血管疾病的危险因素在中度肥胖的个体作为一个功能的差异在一个特定的措施insulin sensitivity.Methods：参与者包括211名明显健康，肥胖（体重指数[计算为体重除以身高米平方]，30.0-34.9）志愿者减肥研究。主要结果的措施包括胰岛素介导的葡萄糖摄取量化的胰岛素抑制试验和代谢变量已知增加2型糖尿病和心血管疾病的风险。与胰岛素敏感性最高的三分之一人群相比，胰岛素抵抗最高的三分之一人群的胰岛素抵抗率显著高于胰岛素敏感性最高的三分之一人群（P <0.05）。
Background: The possibility that substantial heterogeneity in metabolic abnormalities exists in moderately obese individuals has not been emphasized in studies of the effect of obesity on morbidity and mortality. We tested the hypothesis that risk factors for type 2 diabetes mellitus and cardiovascular disease vary dramatically in moderately obese individuals as a function of differences in a specific measure of insulin sensitivity.Methods: Participants included 211 apparently healthy, obese (body mass index [calculated as weight in kilograms divided by height in meters squared], 30.0-34.9) volunteers for weight loss studies. Main outcome measures included insulin-mediated glucose uptake as quantified by the insulin suppression test and metabolic variables known to increase the risk for type 2 diabetes and cardiovascular disease.Results: Insulin sensitivity varied 6-fold. When compared with the most insulin-sensitive third, the most insulin-resistant third of the population had significantly higher (P