Spinal cord mechanisms of chronic pain and clinical implications.
Spinal cord mechanisms of chronic pain and clinical implications.
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DOI：
10.1007/s11916-010-0111-0
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发表时间：
2010-06
影响因子：
3.7
通讯作者：
Cheng, Hsinlin Thomas
中科院分区：
文献类型：
--
作者：
Cheng, Hsinlin Thomas
慢性疼痛是一个普遍的和具有挑战性的问题，大多数医生。由于慢性疼痛涉及复杂的病理机制，最佳治疗仍在开发中。脊髓是外周疼痛信号传递到大脑的重要通道。在慢性疼痛状态下，疼痛刺激触发背角中的传入纤维释放神经肽和神经递质。这些事件在脊髓背角中诱导多种炎症和神经病理过程，并触发局部神经回路的修饰和可塑性。结果，持续的有害信号被放大和延长，这种现象被称为中枢敏感化。本文就与中枢致敏相关的分子事件及其临床意义进行综述。
Chronic pain is a prevalent and challenging problem for most medical practitioners. Due to complex pathological mechanisms involved in chronic pain, optimal treatment is still under development. The spinal cord is an important gateway for peripheral pain signals transmitted to the brain. In chronic pain states, painful stimuli trigger afferent fibers in the dorsal horn to release neuropeptides and neurotransmitters. These events induce multiple inflammatory and neuropathic processes in the spinal cord dorsal horn and trigger modification and plasticity of local neural circuits. As a result, ongoing noxious signals to the brain are amplified and prolonged, a phenomenon known as central sensitization. In this review, the molecular events associated with central sensitization as well as their clinical implications are discussed.
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影响因子：
3.5
作者：
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通讯作者：
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影响因子：
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DOI：
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发表时间：
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