Shear-stress sensitive lenticular vesicles for targeted drug delivery
Shear-stress sensitive lenticular vesicles for targeted drug delivery
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DOI：
10.1038/nnano.2012.84
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发表时间：
2012-08-01
影响因子：
38.3
通讯作者：
Zumbuehl, Andreas
中科院分区：
文献类型：
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作者：
Holme, Margaret N.;Fedotenko, Illya A.;Zumbuehl, Andreas
动脉粥样硬化导致动脉血管变窄，这导致健康动脉和收缩动脉之间的内源性剪切应力发生显著变化。可以在局部释放药物并具有这种流变学变化的纳米容器可能非常有用。在这里，我们表明，由人工1，3-二氨基磷脂制成的囊泡在静态条件下是稳定的，但在升高的剪切应力下释放其内容物。这些囊泡具有透镜状形态，这潜在地导致沿着其赤道沿着的不稳定性。使用模型心血管系统的基础上聚合物管和外部泵代表剪切应力在健康和收缩的血管的心脏，我们表明，药物优先释放收缩的血管中的囊泡具有高剪切应力。
Atherosclerosis results in the narrowing of arterial blood vessels and this causes significant changes in the endogenous shear stress between healthy and constricted arteries. Nanocontainers that can release drugs locally with such rheological changes can be very useful. Here, we show that vesicles made from an artificial 1,3-diaminophospholipid are stable under static conditions but release their contents at elevated shear stress. These vesicles have a lenticular morphology, which potentially leads to instabilities along their equator. Using a model cardiovascular system based on polymer tubes and an external pump to represent shear stress in healthy and constricted vessels of the heart, we show that drugs preferentially release from the vesicles in constricted vessels that have high shear stress.