Role of the medial prefrontal cortex in acquired distinctiveness and equivalence of cues
Role of the medial prefrontal cortex in acquired distinctiveness and equivalence of cues
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DOI：
10.1037/0735-7044.121.6.1431
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发表时间：
2007-12-01
影响因子：
1.9
通讯作者：
Honey, R. C.
中科院分区：
文献类型：
--
作者：
Iordanova, M. D.;Killcross, A. S.;Honey, R. C.
在本研究中，作者研究了内侧前额叶皮层在获得线索的等效性和独特性中的作用。将大鼠置于4个实验环境（A、B、C和D）中，其中它们接受2种听觉刺激（X和Y）的呈现。在情境A和B中，X与食物配对而Y没有，而在情境C和D中，Y与食物配对而X没有。接受假损伤的大鼠和内侧前额叶皮层损伤的大鼠同样容易获得这种神经辨别力。然后，大鼠在A中接受了许多颗粒，但在C中没有。训练后，假损伤大鼠表现出更多的杂志活动在B比在D（获得的独特性/获得的等效性效应），而内侧前额叶皮层损伤没有。这些结果表明，内侧前额叶皮层参与了刺激经验影响它们之间概括程度的过程。
In the present study, the authors examined the role of the medial prefrontal cortex in acquired equivalence and distinctiveness of cues. Rats were placed in 4 experimental contexts (A, B, C, and D) where they received presentations of 2 auditory stimuli (X and Y). In Contexts A and B, X was paired with food and Y was not, whereas in Contexts C and D, Y was paired with food and X was not. Rats that received sham lesions and those with lesions of the medial prefrontal cortex acquired this configural discrimination equally readily. Rats then received many pellets in A but not in C. After this training, sham-lesion rats exhibited more magazine activity in B than in D (an acquired distinctiveness/acquired equivalence effect), whereas those with medial prefrontal cortex lesions did not. These results indicate that the medial prefrontal cortex is involved in the process by which experience with stimuli influences the degree of generalization between them.