Catalase C-262T polymorphism and risk of prostate cancer: Evidence from meta-analysis
Catalase C-262T polymorphism and risk of prostate cancer: Evidence from meta-analysis
复制标题
DOI：
10.1016/j.gene.2015.01.005
复制
发表时间：
2015-03-10
期刊：
影响因子：
3.5
通讯作者：
Niu, Yuanjie
中科院分区：
文献类型：
--
作者：
Hu, Jieping;Feng, Fupeng;Niu, Yuanjie
过氧化氢酶是一种重要的内源性抗氧化酶，其将过氧化氢解毒为氧气和水，从而限制活性氧的有害影响。一些研究调查了过氧化氢酶（CAT）C-262 T基因多态性对前列腺癌（PCa）风险的作用，但得到了相互矛盾的结果。我们基于5项研究进行了荟萃分析，以确定过氧化氢酶C-262 T多态性是否有助于前列腺癌的风险，使用比值比（OR）和95%置信区间（CI）。在等位基因比较模型中，CAT C-262 T基因多态性与PCa的发生有显著相关性（OR = 1.094，95%CI = 1.015-1.178，P = 0.018）。在按种族分层的分析中，在高加索人中发现了相同的结果（等位基因模型OR = 1.090，95% CI = 1.009-1.177，P = 0.028;显性模型OR = 1.108，95% CI = 1.023-1.201，P = 0.012;隐性模型OR = 1.379，纯合子模型OR = 1.429，95%CI = 1.196-1.707，P = 0.000;杂合子模型OR = 1.224，95%CI = 1.020-1.469，P = 0.030）。总之，该荟萃分析表明过氧化氢酶C-262 T多态性与PCa的发生呈正相关。(C)2015 Elsevier B. V.版权所有。
Catalase is an important endogenous antioxidant enzyme that detoxifies hydrogen peroxide to oxygen and water, thus limiting the deleterious effects of reactive oxygen species. Several studies investigated the role of the Catalase (CAT) C-262T gene polymorphism on the risk of prostate cancer (PCa), but get conflicting results. We performed a meta-analysis based on five studies, to determine whether Catalase C-262T polymorphism contributes to the risk of prostate cancer using odds ratios (OR) with 95% confidence intervals (CI). On the whole, our evidence indicates that CAT C-262T polymorphism significantly increases PCa risk in the allele comparison model (OR = 1.094,95% CI = 1.015-1.178, P = 0.018). In the stratified analysis by ethnicity, the same results are found among Caucasians (allele model, OR = 1.090,95% CI = 1.009-1.177, P = 0.028, dominant model, OR = 1.108, 95% Cl = 1.023-1.201, P = 0.012, recessive model, OR = 1.379,95% CI = 1.158-1.641, P = 0.000, homozygous model, OR = 1.429, 95% CI = 1.196-1.707, P = 0.000, and heterozygote model, OR = 1.224,95% Cl = 1.020-1.469, P = 0.030). In conclusion, this meta-analysis suggests a positive correlation between Catalase C-262T polymorphism and the development of PCa. (C) 2015 Elsevier B.V. All rights reserved.