Extracellular Vesicles in Heart Disease: Excitement for the Future ?
Extracellular Vesicles in Heart Disease: Excitement for the Future ?
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DOI：
10.5772/58390
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Das S
中科院分区：
文献类型：
--
作者：
Danielson KM;Das S
细胞外囊泡（EV），包括外来体，微泡和凋亡小体，从许多细胞类型中释放，并参与细胞间通讯，生理功能和疾病的病理。它们已被证明携带和转移广泛的货物，包括蛋白质，脂质和核酸。电动汽车在心脏生理学和心脏病中的作用是一个新兴领域，近年来已经产生了有趣的发现。本文将概述目前已知的关于EV在心血管系统中的作用，包括细胞起源，功能作用和作为生物标志物和潜在治疗方法的效用。
Extracellular vesicles (EV), including exosomes, microvesicles and apoptotic bodies, are released from numerous cell types and are involved in intercellular communication, physiological functions and the pathology of disease. They have been shown to carry and transfer a wide range of cargo including proteins, lipids and nucleic acids. The role of EVs in cardiac physiology and heart disease is an emerging field that has produced intriguing findings in recent years. This review will outline what is currently known about EVs in the cardiovascular system, including cellular origins, functional roles and utility as biomarkers and potential therapeutics.