Conjugation of the ubiquitin family proteins to phospholipids
Conjugation of the ubiquitin family proteins to phospholipids
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泛素家族蛋白与磷脂的缀合
DOI：
10.1080/15548627.2022.2123637
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发表时间：
2022
期刊：
影响因子：
13.3
通讯作者：
Mizushima Noboru
中科院分区：
文献类型：
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作者：
Sakamaki Jun-Ichi;Mizushima Noboru
Atg8家族蛋白与磷脂酰乙醇胺(PE)的结合对于自噬小体的形成是重要的。在泛素家族蛋白中，PE结合被认为是ATG8所特有的。然而，这一教条尚未得到实验验证。我们最近的研究发现，泛素也与PE在内体和液泡(或溶酶体)上偶联。其他泛素样蛋白，如NEDD8和ISG15，也与磷脂共价结合。我们认为与磷脂的结合可能是泛素家族的一个共同特征。
Conjugation of Atg8-family proteins to phosphatidylethanolamine (PE) is important for autophagosome formation. PE conjugation has been thought to be specific to Atg8 among the ubiquitin-family proteins. However, this dogma has not been experimentally verified. Our recent study revealed that ubiquitin is also conjugated to PE on endosomes and the vacuole (or lysosomes). Other ubiquitin-like proteins, such as NEDD8 and ISG15, also covalently bind to phospholipids. We propose that conjugation to phospholipids could be a common feature of the ubiquitin family.