Hypoxia, Angiogenesis, and Colorectal Cancer
Hypoxia, Angiogenesis, and Colorectal Cancer
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DOI：
10.1007/s11888-007-0003-9
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发表时间：
2007-05-01
影响因子：
--
通讯作者：
Chung, Daniel C.
中科院分区：
文献类型：
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作者：
Mizukami, Yusuke;Chung, Daniel C.
血管生成的诱导几乎是实体恶性肿瘤的普遍特征，特异性抑制该过程的治疗策略现已进入临床竞技场。结直肠癌是高度血管生成的，并且是对抗血管生成治疗表现出显著反应的第一种肿瘤类型。多种遗传和环境刺激诱导血管生成表型。这些分子通路的表征以及它们复杂的相互作用正在迅速发展，更全面的理解对于优化治疗方法至关重要。
The induction of angiogenesis is a nearly universal feature of solid malignancies, and therapeutic strategies that specifically inhibit this process have now entered the clinical arena. Colorectal cancers are highly angiogenic and were the first tumor type to exhibit significant responses to anti-angiogenic therapy. Multiple genetic and environmental stimuli induce the angiogenic phenotype. The characterization of these molecular pathways as well as their complex interactions is rapidly evolving, and a more comprehensive understanding is essential to optimize therapeutic approaches.