Viral genotypes and response to interferon in patients with acute prolonged hepatitis B virus infection of adulthood in japan
Viral genotypes and response to interferon in patients with acute prolonged hepatitis B virus infection of adulthood in japan
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DOI：
10.1002/jmv.10239
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发表时间：
2002-12-01
影响因子：
12.7
通讯作者：
Kumada, H
中科院分区：
文献类型：
--
作者：
Kobayashi, M;Arase, Y;Kumada, H
日本东京虎门医院收治的57名成人被诊断为急性乙型肝炎病毒（HBV）感染。通过血清学方法确定了HBV基因型，并与1077名慢性乙型肝炎患者的基因型进行了比较。基因型分布情况如下：基因型A（急性为22.8%，慢性为1.9%；P<0.00001）；B（14.0%对9.4%）；C（43.9%对87.7%，P = 0.004）；D（1.8%对0.2%）；F（1.8%对0.2%）；无法分型（15.8%对0.6%，P = 0.001）。其中7人（12%）感染持续。他们包括在疾病急性期接受泼尼松龙或甘草酸苷治疗的7名患者中的6名（86%）以及未接受治疗的41名患者中的1名（2%）（P = 0.01）。对7名急性迁延性HBV感染患者给予干扰素治疗，其中4名患者血清中的乙型肝炎e抗原（HBeAg）和表面抗原（HBsAg）转阴。在这4名有应答的患者中，1名感染HBV基因型B，3名感染基因型C。其余3名患者HBsAg持续阳性，他们均感染HBV基因型A，其中1名患者HBeAg仍为阳性。这些结果表明，HBV基因型A在日本急性乙型肝炎患者中占优势，并提示干扰素对成人急性迁延性HBV感染患者有较高疗效，但感染HBV基因型C的患者除外。2002威利 - 利斯公司
Acute hepatitis B virus (HBV) infection was diagnosed in 57 adults admitted to Toranomon Hospital in Tokyo, Japan. Genotypes of HBV were determined by a serological method and compared to those in 1,077 patients with chronic hepatitis B. The distribution of genotypes were: genotype A (acute, 22.8% vs. chronic, 1.9%; P< 0.00001); B (14.0% vs. 9.4%); C (43.9% vs. 87.7%, P=0.004); D (1.8% vs. 0.2%); F (1.8% vs. 0.2%); and unable to be typed (15.8% vs. 0.6%, P= 0.001). The infection persisted in seven (12%) of them. They included six (86%) of the seven patients who received prednisolone or glycyrrhizin during an acute phase of illness and one of the 41 (2%) who did not (P=0.01). Interferon was given to the seven patients with acute prolonged HBV infection, and four of them responded by clearing hepatitis B e antigen (HBeAg) and surface antigen (HBsAg) from serum. Of the four responders, one was infected with HBV genotype B and three with genotype C. HBsAg persisted in the remaining three patients all of whom were infected with HBV genotype A, and HBeAg stayed positive in one of them. These results indicate that HBV genotype A prevails in Japanese patients with acute hepatitis B, and suggest a high efficacy of interferon in the adult patients with acute prolonged HBV infection, except in those infected with HBV genotype (C) 2002 Wiley-Liss, Inc.