Circadian Oscillators: Around the Transcription-Translation Feedback Loop and on to Output.
Circadian Oscillators: Around the Transcription-Translation Feedback Loop and on to Output.
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DOI：
10.1016/j.tibs.2016.07.009
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发表时间：
2016-10
影响因子：
13.8
通讯作者：
Dunlap JC
中科院分区：
文献类型：
--
作者：
Hurley JM;Loros JJ;Dunlap JC
从蓝藻到哺乳动物，生物进化出了适应环境变化的计时机制，以优化生存和提高适应能力。为了预测这些有规律的每日周期，许多生物体表现出近24小时的细胞自主振荡，这些振荡由控制广泛生物过程的基于转录的或转录后的负反馈环维持。为了确定蓝藻、真菌和动物时钟之间新出现的共同主题，讨论了在理解调节这些振荡器及其输出的机制方面的一些重大最新进展。这些包括反义转录的作用，内在无序的蛋白质，时钟基因中的密码子偏向，以及作为振荡器和输出的一部分，更集中地讨论转录后和翻译调控。
From cyanobacteria to mammals, organisms have evolved timing mechanisms to adapt to environmental changes in order to optimize survival and improve fitness. To anticipate these regular daily cycles, many organisms manifest near 24-h cell-autonomous oscillations that are sustained by transcription–translation-based or post-transcriptional negative feedback loops that control a wide range of biological processes. With an eye to identifying emerging common themes among cyanobacterial, fungal and animal clocks, some major recent developments in the understanding of the mechanisms that regulate these oscillators and their output are discussed. These include roles for antisense transcription, intrinsically disordered proteins, codon bias in clock genes, and a more focused discussion of post-transcriptional and translational regulation as a part of both the oscillator and output.