Heritability estimates for psychotic disorders -: The Maudsley Twin psychosis series
Heritability estimates for psychotic disorders -: The Maudsley Twin psychosis series
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DOI：
10.1001/archpsyc.56.2.162
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发表时间：
1999-02-01
影响因子：
--
通讯作者：
Murray, RM
中科院分区：
文献类型：
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作者：
Cardno, AG;Marshall, EJ;Murray, RM
背景资料：以前的双胞胎研究支持遗传贡献的主要类别的精神病性障碍，但很少有这些已采用操作的诊断标准，并没有这样的研究一直是基于一个样本，其中包括所有的功能性精神病性障碍。共有224名双胞胎先证者（106个单合子，从英国伦敦以服务为基础的Maudsley双胞胎登记处确定了118例（双卵型）与同性双胞胎和精神病终身病史。研究诊断标准精神病诊断是在终生的基础上进行的。还进行了DSM-III-R和国际疾病统计分类第10次修订版精神分裂症的主要终身诊断。Pro-bandwise一致率和相关性的责任进行了计算，和生物统计模型fitting.Results：一个重大的遗传贡献的变异责任确认的主要诊断类别，除了研究诊断标准抑郁性精神病和未指明的功能性精神病，在家庭传播得到证实，但遗传和共同的环境因素的相对贡献尚不清楚。研究诊断标准精神分裂症、情感障碍、躁狂症、DSM-III-R精神分裂症和国际疾病统计分类第10次修订版精神分裂症的遗传度估计值均在82%至85%之间。没有一个估计显着不同的任何其他。结论：精神分裂症，情感障碍，躁狂症的遗传度估计是实质性的和相似的。人群发病风险估计是推断的，而不是直接测量的，但结果与直接估计发病风险的研究非常相似。
Background: Previous twin studies have supported a genetic contribution to the major categories of psychotic disorders, but few of these have employed operational diagnostic criteria, and no such study has been based on a sample that included the full range of functional psychotic disorders.Methods: A total of 224 twin probands (106 monozygotic, 118 dizygotic) with a same-sex co-twin and a lifetime history of psychosis was ascertained from the service-based Maudsley Twin Register in London, England. Research Diagnostic Criteria psychotic diagnoses were made on a lifetime-ever basis. Main-lifetime diagnoses of DSM-III-R and International Statistical Classification of Diseases, 10th Revision schizophrenia were also made. Pro-bandwise concordance rates and correlations in liability were calculated, and biometrical model fitting applied.Results: A substantial genetic contribution to variance in liability was confirmed for the major diagnostic categories except Research Diagnostic Criteria depressive psychosis and unspecified functional psychosis, where familial transmission was confirmed, but the relative contribution of genetic and common environmental factors was unclear. Heritability estimates for Research Diagnostic Criteria schizophrenia, schizoaffective disorder, mania, DSM-III-R schizophrenia, and International Statistical Classification of Diseases, 10th Revision schizophrenia were all between 82% and 85%. None of the estimates differed significantly from any other.Conclusions: Heritability estimates for schizophrenia, schizoaffective disorder, and mania were substantial and similar. Population morbid risk estimates were inferred rather than directly measured, but the results were very similar to those from studies where morbid risks were directly estimated.