The FUNPET-a New Hybrid Ion Funnel-Ion Carpet Atmospheric Pressure Interface for the Simultaneous Transmission of a Broad Mass Range
The FUNPET-a New Hybrid Ion Funnel-Ion Carpet Atmospheric Pressure Interface for the Simultaneous Transmission of a Broad Mass Range
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DOI：
10.1007/s13361-018-2038-3
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发表时间：
2018-11-01
影响因子：
3.2
通讯作者：
Jarrold, Martin F.
中科院分区：
文献类型：
--
作者：
Draper, Benjamin E.;Anthony, Staci N.;Jarrold, Martin F.
大气压力接口将离子从环境压力传输到质谱仪的低压环境。与离子漏斗耦合的毛细管被广泛使用。然而，传统的离子漏斗对于抵消高质量离子从流经毛细管的气流中获取的大量能量几乎没有作用。关于气流对离子传输的影响的研究还很少，之前的研究都仅限于低质量、低电荷的离子。在这项工作中，我们考虑了气流、扩散和电场（静态和振荡）对离子轨迹的影响，并使用模拟来设计一种新的混合离子漏斗-离子毯 (FUNPET) 接口，该接口可在一组仪器条件下传输广泛的质量范围。该设计采用了虚拟射流干扰器，其中压力积聚和逆流消散了气流进入界面所产生的超音速射流。这以及可与 FUNPET 一起使用的小出口孔径，减少了进入差动泵的下一阶段的气流。虚拟射流干扰器对各种质量（1kDa 至 1GDa）的离子进行热化，一旦热化，它们就会以低过剩动能传输到质谱仪的下一个区域。 FUNPET 接口很容易由柔性印刷电路板和 3D 打印制成的支撑框架制造而成。使用电荷检测质谱法评估界面的性能。
An atmospheric pressure interface transports ions from ambient pressure to the low-pressure environment of a mass spectrometer. A capillary coupled to an ion funnel is widely used. However, conventional ion funnels do little to negate the large amount of energy picked up by high-mass ions from the gas flow through the capillary. There has been little work done on the effects of gas flow on ion transmission, and the previous studies have all been limited to low-mass, low-charge ions. In this work, we account for the effects of gas flow, diffusion, and electric fields (static and oscillating) on ion trajectories and use simulations to design a new hybrid ion funnel-ion carpet (FUNPET) interface that transmits a broad mass range with a single set of instrument conditions. The design incorporates a virtual jet disruptor where pressure buildup and counter flow dissipate the supersonic jet that results from gas flow into the interface. This, and the small exit aperture that can be used with the FUNPET, reduces the gas flow into the next stage of differential pumping. The virtual jet disruptor thermalizes ions with a broad range of masses (1kDa to 1GDa), and once thermalized, they are transmitted into next region of the mass spectrometer with low excess kinetic energy. The FUNPET interface is easy to fabricate from flexible printed circuit board and a support frame made by 3D printing. The performance of the interface was evaluated using charge detection mass spectrometry.