Opinion paper: Stimulation of complement amplification or activation of the alternative pathway of complement?
Opinion paper: Stimulation of complement amplification or activation of the alternative pathway of complement?
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DOI：
10.1016/j.molimm.2007.06.146
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发表时间：
2007-09-01
影响因子：
3.6
通讯作者：
Alaia, Velia
中科院分区：
文献类型：
--
作者：
Lutz, Hans U.;Fumia, Sandra;Alaia, Velia
在本意见文件中，我们建议应重新拟订补编制度的方案，以便更好地说明其效力。这可以通过将替代补体途径的扩增环置于补体系统的中心来实现。这种排列强调了C3b分子通过任何途径产生，都可以刺激补体扩增。此外，它允许人们区分这种类型的扩增刺激和由捕获二聚体C3b分子的免疫复合物驱动的刺激，后者是比C3b更有效的C3转化酶前体。类似于所绘制的方案可能有助于更好地说明途径的相互作用，并传达对补体系统机制的更清晰理解。(c) 2007 Elsevier Ltd.版权所有。
In this opinion paper, we suggest that the scheme of the complement system should be redrawn in order to better illustrate its potencies. This can be achieved by putting the amplification loop of the alternative complement pathway at the center of the complement system. This arrangement emphasizes that C3b molecules, generated by any pathway, can stimulate complement amplification. Furthermore, it allows one to differentiate between this type of stimulation of amplification and that driven by those immune complexes that capture dimeric C3b molecules, which are more potent C3 convertase precursors than C3b. Schemes similar to the one drawn may help to better illustrate the interplay of the pathways and convey a clearer comprehension of the mechanics of the complement system. (c) 2007 Elsevier Ltd. All rights reserved.