MCO Membranes: Enhanced Selectivity in High-Flux Class.
MCO Membranes: Enhanced Selectivity in High-Flux Class.
复制标题
MCO膜：高流量类别的选择性增强。
DOI：
10.1038/srep18448
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发表时间：
2015-12-16
影响因子：
4.6
通讯作者：
Krause B
中科院分区：
文献类型：
--
作者：
Boschetti-de-Fierro A;Voigt M;Storr M;Krause B
用于血液透析的新型MCO高通量膜已经开发出来，具有优化的渗透性，允许接近天然肾脏的过滤。一个全面的体外表征膜性能的葡聚糖过滤。描述了原始膜以及暴露于血液40分钟的膜的筛分概况。有效孔径（斯托克斯-爱因斯坦半径）估计从过滤实验之前和之后的血液暴露，并将结果进行比较，流体动力学半径的中型和大型尿毒症毒素和必需蛋白质。结果表明，MCO膜的定制孔径促进了大毒素的去除，同时确保了白蛋白的保留。
Novel MCO high-flux membranes for hemodialysis have been developed with optimized permeability, allowing for filtration close to that of the natural kidney. A comprehensive in vitro characterization of the membrane properties by dextran filtration is presented. The sieving profile of pristine membranes, as well as that of membranes exposed to blood for 40 minutes, are described. The effective pore size (Stokes-Einstein radius) was estimated from filtration experiments before and after blood exposure, and results were compared to hydrodynamic radii of middle and large uremic toxins and essential proteins. The results indicate that the tailored pore sizes of the MCO membranes promote removal of large toxins while ensuring the retention of albumin.