Comorbidity in older adults with cancer.
Comorbidity in older adults with cancer.
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DOI：
10.1016/j.jgo.2015.12.002
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发表时间：
2016-07
影响因子：
3
通讯作者：
Holmes H
中科院分区：
文献类型：
--
作者：
Williams GR;Mackenzie A;Magnuson A;Olin R;Chapman A;Mohile S;Allore H;Somerfield MR;Targia V;Extermann M;Cohen HJ;Hurria A;Holmes H
由于人口结构的变化和65岁以上癌症患者人数的增加，科摩罗是一个日益重要的问题。老年人共病的临床管理和决策的最佳方法仍不清楚。2015年5月，癌症和衰老研究小组与国家癌症研究所和国家衰老研究所合作，讨论了老年癌症患者干预研究的设计和实施。包括对共病测量、干预措施和未来研究的介绍和讨论。在这篇文章中，我们讨论了癌症合并症的相关性，检查常用的工具来衡量合并症，并讨论了未来的合并症研究方向。简化标准化的合并症测量，放宽临床试验的合格标准，并利用新的试验设计是至关重要的，以开发一个更大的和更普遍的证据基础，以指导这些患者的管理。创建或调整用于老年癌症患者的合并症管理策略是必要的，以确定为这一不断增长的人口的最佳护理。
Comorbidity is an issue of growing importance due to changing demographics and the increasing number of adults over the age of 65 with cancer. The best approach to the clinical management and decision-making in older adults with comorbid conditions remains unclear. In May 2015, the Cancer and Aging Research Group in collaboration with the National Cancer Institute and National Institute on Aging met to discuss the design and implementation of intervention studies in older adults with cancer. A presentation and discussion on comorbidity measurement, interventions, and future research was included. In this article we discuss the relevance of comorbidities in cancer, examine the commonly used tools to measure comorbidity, and discuss the future direction of comorbidity research. Incorporating standardized comorbidity measurement, relaxing clinical trial eligibility criteria, and utilizing novel trial designs are critical to developing a larger and more generalizable evidence base to guide the management of these patients. Creating or adapting comorbidity management strategies for use in older adults with cancer is necessary to define optimal care for this growing population.