The chemopreventive effects of tea on human oral precancerous mucosa lesions
The chemopreventive effects of tea on human oral precancerous mucosa lesions
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DOI：
10.1046/j.1525-1373.1999.d01-37.x
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发表时间：
1999-04-01
影响因子：
--
通讯作者：
Chen, JS
中科院分区：
文献类型：
--
作者：
Li, N;Sun, Z;Chen, JS
采用自制的混合茶对口腔粘膜白斑患者进行双盲干预试验。将59例经临床和病理确诊的口腔粘膜白斑患者随机分为治疗组（口服3g混合茶并局部治疗）和对照组（安慰剂和甘油治疗）。治疗6个月后，29例患者中37.9%的患者口腔病变缩小，3.4%的患者口腔病变增大;对照组30例中，10.0%的患者口腔病变减轻，6.7%的患者口腔病变加重。治疗组口腔粘膜脱落细胞微核发生率（5.4/1000细胞）低于对照组（每1000个细胞11.3个）（P < 0.01）;而在20名健康受试者中每1000个细胞中有1.4个，外周血淋巴细胞微核率和染色体畸变率也显示相同的结果。病理检查中，治疗组与对照组口腔粘膜细胞核AgNOR银染数目、总体积及增殖细胞核抗原（PCNA）增殖指数比较，差异有显著性意义（P < 0.05），表明治疗组口腔粘膜细胞增殖能力下降。总体结果为茶对口腔癌的保护作用提供了一些直接证据。
A double-blind intervention trial was conducted in patients with oral mucosa leukoplakia using a mixed tea product developed by the authors. Fifty-nine oral mucosa leukoplakia patients, diagnosed by established clinical and pathological criteria, were randomly divided into a treated group (3 g mixed tea oral administration and topical treatment) and a control group (placebo and glycerin treatment). After the 6-month trial, the size of oral lesion was decreased in 37.9% of the 29 treated patients and increased in 3.4%; whereas the oral lesion was decreased in 10.0% of the 30 control patients and increased in 6.7%, At the same time, the incidence of micronucleated exfoliated oral mucosa cells in the treated group (5.4 per 1000 cells) was lower than that in the control group (11.3 per 1000 cells)(P < 0.01); whereas it was 1.4 per 1000 cells in 20 healthy subjects, The micronuclei and chromosome aberration rate in the peripheral blood lymphocytes showed the same results. In pathological examination, there were significant differences (P < 0.05) in the number and total volume of the silver-stained Nucleolar Organizer Regions (AgNOR) and the proliferating index of Proliferation Cell Nuclear Antigen (PCNA) in oral mucosa cell nuclei between the treated group and the control group which indicates that cell proliferation was decreased in the treated patients. The overall results provide some direct evidence on the protective effects of tea on oral cancer.