Cataract extraction and cognitive function in older women
Cataract extraction and cognitive function in older women
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DOI：
10.1097/01.ede.0000083503.34133.8c
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发表时间：
2003-07-01
期刊：
影响因子：
5.4
通讯作者：
Hankinson, SE
中科院分区：
文献类型：
--
作者：
Grodstein, F;Chen, J;Hankinson, SE
背景：氧化损伤是白内障的重要病因。因此，白内障和其他健康终点之间的关联可能表明共同的病因作用的氧化stress.Methods：为了评估任何作用的氧化应激在认知功能和早期认知能力下降，我们调查了认知和白内障摘除术之间的关系，在16,197社区居住的妇女年龄70-79岁的护士健康研究。从1995年至2000年，通过电话进行了六次认知测试;第二次访谈正在进行中，已对12 995名妇女进行了访谈。总共有3，597名女性在基线认知评估之前报告了白内障摘除术。我们使用逻辑回归来计算多变量调整的相对风险的低评分和大幅下降，比较那些与和没有白内障extract.Results：使用一个整体评分，结合认知测试的结果，有没有白内障和低评分之间的关系（RR = 0.99; 95% CI = 0.87-1.13）或从基线到第二次访谈的显著下降（RR = 1.08; CI = 0.93-1.25）。结论：白内障摘除术似乎与这些妇女的认知功能无关。
Background: Oxidative damage is critical in the etiology of cataract. Therefore, associations between cataract and other health endpoints may suggest the shared etiologic role of oxidative stress.Methods: To assess any role of oxidative stress in cognitive function and early cognitive decline, we investigated the relation between cognition and cataract extraction in 16,197 community-dwelling women age 70-79 years from the Nurses' Health Study. Six cognitive tests were administered by telephone from 1995 to 2000; second interviews are ongoing and have been completed for 12,995 women. In total, 3,597 women reported cataract extraction prior to their baseline cognitive assessment. We used logistic regression to calculate multivariate-adjusted relative risks of a low score and of substantial decline, comparing those with and without cataract extraction.Results: Using a global score that combines the results of the cognitive tests, there was no relation between cataract and either low score (RR = 0.99; 95% CI = 0.87-1.13) or substantial decline from baseline to second interview (RR = 1.08; CI = 0.93-1.25).Conclusion: Cataract extraction does not appear to be related to cognitive function in these women.