Polyacrylamide gel containing egg white as new model for irradiation experiments using focused ultrasound
Polyacrylamide gel containing egg white as new model for irradiation experiments using focused ultrasound
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DOI：
10.1016/j.ultrasmedbio.2004.07.016
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发表时间：
2004-10-01
影响因子：
2.9
通讯作者：
Nagawa, H
中科院分区：
文献类型：
--
作者：
Takegami, K;Kaneko, Y;Nagawa, H
介绍了一种用于高强度聚焦超声HIFU辐照实验的新型模型--含有蛋清的聚丙烯酰胺凝胶。凝胶是透明的，除了白色的热坏死区。该模型与含有牛血清白蛋白(BSA)蛋白的凝胶相似，并具有相同的好处，但鸡蛋比BSA便宜。凝胶的声学性能非常好，与软组织相似，密度为1.0g/cm(3)，声速为154m/S，在2 MHz下的声衰减为0.4dB/cm。我们说明了这种凝胶在显示HIFU损伤方面的有效性，并介绍了一种新的兔胃黏膜下肿瘤模型，表明这种GET可以形成任何所需的形状。我们的含有蛋清的PAA凝胶是适合HIFU实验应用的一次性声学材料的有吸引力的候选者。(C)2004年世界医学生物学超声联合会。
A polyacrylamide (PAA) gel containing egg white as a new model for irradiation experiments in high-intensity focused ultrasound HIFU is introduced. The gel is transparent except in thermally necrosed regions which are white. The model is similar to, and has the same benefits as, gels containing bovine serum albumin (BSA) protein, but egg is less expensive than BSA. The acoustic properties of the gel are very favorable, similar to those of soft tissues; density 1.0 g/cm(3), sound speed 1540 m/s and acoustic attenuation 0.4 dB/cm at 2 MHz. We illustrate the usefulness of the gel in visualizing HIFU lesions and introduce a new model of gastric submucosal tumor in a rabbit stomach, showing that this get can be formed into any desired shape. Our PAA gel containing egg white is an attractive candidate for a disposable acoustic material suitable for experimental applications of HIFU. (C) 2004 World Federation for Ultrasound in Medicine Biology.