Cerebrovascular reactivity to carbon dioxide in Alzheimer's disease.
Cerebrovascular reactivity to carbon dioxide in Alzheimer's disease.
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DOI：
10.3233/jad-122011
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
de Leon MJ
中科院分区：
文献类型：
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作者：
Glodzik L;Randall C;Rusinek H;de Leon MJ
越来越多的证据表明，脑血管对二氧化碳的反应性（CVRCO 2）在阿尔茨海默病（AD）中受损。临床前和动物研究表明，AD患者脑血管存在慢性过度收缩。我们回顾了（a）AD患者CVRCO 2受损机制的临床前研究;（B）AD痴呆、轻度认知障碍（MCI）和正常认知受试者脑血管功能的临床研究。虽然临床研究的结果是不确定的，越来越多的报告显示，血管反应性受损的二氧化碳与AD的主题，也可能在MCI。因此，CVRCO 2可能是检测风险受试者早期血管功能障碍的一种有吸引力的方法。
There is growing evidence that cerebrovascular reactivity to carbon dioxide (CVRCO2) is impaired in Alzheimer’s disease (AD). Preclinical and animal studies suggest chronic hypercontractility in brain vessels in AD. We review (a) preclinical studies of mechanisms for impaired CVRCO2 in AD; (b) clinical studies of cerebrovascular function in subjects with AD dementia, mild cognitive impairment (MCI), and normal cognition. Although results of clinical studies are inconclusive, an increasing number of reports reveal an impairment of vascular reactivity to carbon dioxide in subjects with AD, and possibly also in MCI. Thus, CVRCO2 may be an attractive means to detect an early vascular dysfunction in subjects at risk.