Opiate Receptors and Endorphins
Opiate Receptors and Endorphins
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阿片受体和内啡肽
DOI：
10.1300/j251v01n01_03
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
E. J. Simon
中科院分区：
文献类型：
--
作者：
E. J. Simon
本文按时间顺序讨论了阿片受体和内源性阿片肽的发现。在总结了受体及其内源性配体的性质和分布后，讨论了内源性阿片系统的可能功能。证据表明，该系统在内源性疼痛调节和阿片成瘾中发挥作用。强调了证据的性质，以及缺乏阿片受体-内啡肽系统因果参与的确凿证据。
This review presents a chronological discussion of the discovery of opiate receptors and the endogenous opioid peptides. After a summary of the properties and distribution of the receptors and their endogenous ligands, the possible function of the endogenous opioid system is discussed. Evidence for a role of this system in endogenous pain modulation and in opiate addiction is presented. The nature of the evidence and the absence of definitive proof of a causal involvement of the opiate receptor-endorphin system are emphasized.