DISTRIBUTION OF NEURONS IN THE MAJOR PELVIC GANGLION OF THE RAT WHICH SUPPLY THE BLADDER, COLON OR PENIS
DISTRIBUTION OF NEURONS IN THE MAJOR PELVIC GANGLION OF THE RAT WHICH SUPPLY THE BLADDER, COLON OR PENIS
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DOI：
10.1007/bf00224723
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发表时间：
1989-04-01
影响因子：
3.6
通讯作者：
DEGROAT, WC
中科院分区：
文献类型：
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作者：
KEAST, JR;BOOTH, AM;DEGROAT, WC
在雄性大鼠中，支配盆腔器官的大量节后神经元位于盆大神经节中。在本研究中，我们已经确定了神经元的神经节内的位置，这些神经元投射到三个盆腔器官中的任何一个，阴茎，结肠或膀胱。使用两种荧光逆行转运染料，固蓝和荧光金。对于大多数动物，将一种染料注射到阴茎的海绵体间隙、远端结肠壁或膀胱壁中。在少数动物中，两个器官被注射，每个器官都有不同的染料。注射后1 - 6周，将主要盆神经节固定在缓冲甲醛中。荧光染料标记的细胞分布在整个安装的完整的神经节，在大多数情况下，也在小的副神经节位于输尿管和前列腺之间。这些研究显示了每个器官特异性神经元组的独特分布模式。大多数结肠神经元位于骨盆神经入口附近的主要骨盆神经节中，而几乎所有阴茎神经元都位于阴茎神经附近或阴茎神经内。膀胱神经元相对均匀地分布在整个神经节中。这些结果表明，一个独特的地形组织的器官特异性神经元的主要骨盆神经节的雄性大鼠，这种现象也已观察到在其他外周神经节。
In male rats a large number of the postganglionic neurons which innervate the pelvic organs are located in the major pelvic ganglion. In the present study we have identified the location within this ganglion of neurons which project to either of three pelvic organs, the penis, colon or urinary bladder. Two fluorescent retrogradely-transported dyes, Fast Blue and Fluoro-Gold, were used. For most animals one dye was injected into the cavernous space of the penis, the wall of the distal colon or the wall of the urinary bladder. In a small number of animals two organs were injected, each with a different dye. One to six weeks after injection the major pelvic ganglia were fixed in buffered formaldehyde. The distribution of fluorescent dye-labelled cells was observed in whole mounts of complete ganglia and, in most cases, also in small accessory ganglia located between the ureter and the prostate. The studies showed a unique pattern of distribution for each organ-specific group of neurons. Most of the colon neurons are located in the major pelvic ganglion near the entrance of the pelvic nerve, whereas almost all of the penis neurons are near or within the penile nerve. Bladder neurons are relatively evenly distributed throughout the ganglion. These results demonstrate a distinct topographical organization of organ-specific neurons of the major pelvic ganglion of the male rat, a phenomenon which has also been observed in other peripheral ganglia.