Double-negative T cells during HIV/SIV infections: potential pinch hitters in the T-cell lineup.
Double-negative T cells during HIV/SIV infections: potential pinch hitters in the T-cell lineup.
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DOI：
10.1097/coh.0b013e3283504a66
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发表时间：
2012-03
影响因子：
4.1
通讯作者：
Sodora DL
中科院分区：
文献类型：
--
作者：
Sundaravaradan V;Mir KD;Sodora DL
这篇综述总结了 CD3+CD4−CD8− 双阴性 T 细胞的作用，它们具有调节性 T 细胞和辅助性 T 细胞功能，并且可能有可能补偿 SIV/HIV 感染期间 CD4+ T 细胞水平的降低。双阴性 (DN) T 细胞在多种人类疾病以及自身免疫和移植的小鼠模型中得到了表征，它们表现出免疫调节和辅助 T 细胞样功能。在非洲非人灵长类动物自然非致病性 SIV 感染期间，临床疾病进展的缺乏与 DN T 细胞的存在有关，DN T 细胞维持辅助 T 细胞功能，同时保持对病毒感染的抵抗力。此外，DN T 细胞可以补偿在一群乌白眉猴中观察到的非常低水平的 CD4+ T 细胞，这些乌白眉猴已经感染 SIV 10 多年，并且没有出现与艾滋病相关的临床疾病表现。这些研究确定了 DN T 细胞在 HIV 感染期间提供关键辅助功能的潜力。具有某些 CD4+ T 细胞功能的 DN T 细胞与 SIV 感染期间的非致病性结果相关，并且代表了 HIV 感染患者的潜在免疫治疗靶点。
This review summarizes the role of CD3+CD4−CD8− double-negative T cells, which have both regulatory and helper T cell function and may have the potential to compensate for the reduced levels of CD4+ T cells during SIV/HIV infection. Double-negative (DN) T cells have been characterized in several human diseases and in murine models of autoimmunity and transplantation, where they exhibit both immunoregulatory and helper T cell-like function. During the natural nonpathogenic SIV infection of African nonhuman primates, the lack of clinical disease progression is associated with the presence of DN T cells that maintain helper T cell functions while remaining refractory to viral infection. Moreover, DN T cells may compensate for very low levels of CD4+ T cells observed in a cohort of sooty mangabeys that have been infected with SIV for over 10 years and have remained free of clinical disease manifestations associated with AIDS. These studies identify a potential for DN T cells to provide critical helper function during HIV infection. DN T cells with some CD4+ T cell functions are associated with a nonpathogenic outcome during SIV infection and represent a potential immune therapeutic target in HIV-infected patients.