Effect of MLS® Laser Therapy with Different Dose Regimes for the Treatment of Experimentally Induced Tendinopathy in Sheep: Pilot Study
Effect of MLS® Laser Therapy with Different Dose Regimes for the Treatment of Experimentally Induced Tendinopathy in Sheep: Pilot Study
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DOI：
10.1089/pho.2014.3775
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发表时间：
2015-03-01
影响因子：
--
通讯作者：
Busetto, Roberto
中科院分区：
文献类型：
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作者：
Iacopetti, Ilaria;Perazzi, Anna;Busetto, Roberto
目的：探讨弱激光多波锁定系统(MLS(R))对胶原酶诱导的绵羊肌腱损伤急性期的治疗作用。背景资料：肌腱损伤在人类运动员和运动马中很常见，需要很长的恢复时间，并且有很高的复发风险。许多传统的治疗方法不能正确修复损伤的肌腱组织。近年来，低强度激光治疗(LLLT)在不同肌肉骨骼疾病的炎症调节方面产生了有趣的结果。方法：第1组采用5 J/cm(2)能量密度的MLS激光照射左后肢10个疗程。第2组接受10次MLS激光治疗，照射剂量为2.5J/cm(2)。两组受试者均以右后肢为对照。结果：术后进行了临床随访和B超检查，并于首次激光治疗后第30天进行了组织学检查。特别是，组织学检查的结果表明，这两种处理都导致了统计学上显著的细胞数量减少，尽管只有第二组的细胞数量恢复正常。MLS激光治疗剂量为2.5J/cm(2)时，血管面积明显减小。结论：在这项研究中，临床和组织学评估表明，治疗剂量
Objective: The aim of this preliminary study was to investigate the effect of Multiwave Locked System (MLS (R)), a particular model of low-level laser, in the acute phase of collagenase-induced tendon lesions in six adult sheep randomly assigned to two groups. Background data: Tendon injuries are common among human athletes and in sport horses, require a long recovery time, and have a high risk of relapse. Many traditional treatments are not able to repair the injured tendon tissue correctly. In recent years, the use of low-level laser therapy (LLLT) produced interesting results in inflammatory modulation in different musculoskeletal disorders. Methods: Group 1 received 10 treatments of MLS laser therapy at a fluence of 5 J/cm(2) on the left hindlimb. Group 2 received 10 treatments of MLS laser therapy at a fluence of 2.5 J/cm(2) on the left hindlimb. In every subject in both groups, the right hindlimb was considered as the control leg. Results: Clinical follow-up and ultrasonography examinations were performed during the postoperative period, and histological examinations were performed at day 30 after the first application of laser therapy. In particular, results from histological examinations indicate that both treatments induced a statistically significant cell number decrease, although only in the second group did the values return to normal. Moreover, the MLS laser therapy dose of 2.5 J/cm(2) (group 2) caused a significant decrease of vessel area. Conclusions: In this study, clinical and histological evaluation demonstrated that a therapeutic dose