Hyperactivity and impulsiveness in rats fed diets supplemented with either Aroclor 1248 or PCB-contaminated St. Lawrence river fish
Hyperactivity and impulsiveness in rats fed diets supplemented with either Aroclor 1248 or PCB-contaminated St. Lawrence river fish
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DOI：
10.1016/s0166-4328(01)00244-3
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发表时间：
2001-11-29
影响因子：
2.7
通讯作者：
Quimby, F
中科院分区：
文献类型：
--
作者：
Berger, DF;Lombardo, JP;Quimby, F
我们研究了青春期周围暴露于多氯联苯（PCB）是否会导致成年Sprague-Dawley大鼠的多动症和冲动。随机分配的组食用的食物含有环境浓度的多氯联苯1248，多氯联苯污染的圣劳伦斯河鲤鱼，或玉米油（控制）。所有患者均接受最终多次（mult）120-s、固定间隔（FI）、5分钟消退（EXT）时间表的操作性训练。两个暴露组的水滴按压率平均为对照组的1.5倍以上，特别是在120秒间隔结束时。这种过度活跃包括短（小于或等于0.5秒）的相互反应时间（IRT），行为特征的过度活跃的男孩和遗传性过度活跃的大鼠。暴露组也过度反应的强化密度与过渡到最终的时间表相关的下降。这些结果被解释为动物强化机制的可能改变和PCB暴露的可能神经毒性效应。(C)2001爱思唯尔科技有限公司。保留所有权利。
We examined whether exposure to polychlorinated biphenyls (PCBs) around puberty would produce hyperactivity and impulsiveness in adult Sprague-Dawley rats. Randomly assigned groups consumed food containing environmental concentrations of Aroclor 1248, PCB-contaminated St. Lawrence River carp, or corn oil (control). All received operant training to a final multiple (mult) 120-s, fixed interval (FI), 5-min extinction (EXT) schedule. Pressing rates of both exposed groups for drops of water averaged more than 1.5 times that of controls, especially toward the end of the 120-s interval. This overactivity included bursts with short (less than or equal to 0.5 s) interresponse times (IRTs), behavior characteristic of hyperactive boys and genetically hyperactive rats. The exposed groups also overreacted to the decreases in reinforcement density associated with transition to the final schedule. The results were interpreted in terms of the possible alterations in the animals' reinforcement mechanisms and the possible neurotoxic effects of PCB exposure. (C) 2001 Elsevier Science B.V. All rights reserved.