A short-term admission improved brachial-ankle pulse wave velocity in type 2 diabetic patients
A short-term admission improved brachial-ankle pulse wave velocity in type 2 diabetic patients
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DOI：
10.1016/j.diabres.2005.04.009
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发表时间：
2005-12-01
影响因子：
5.1
通讯作者：
Yasuda, H
中科院分区：
文献类型：
--
作者：
Yamamoto, A;Katayama, Y;Yasuda, H
臂踝脉搏波速度(BaPWV)是一种评估动脉硬化相关动脉僵硬的无创性方法。我们检查了在为期两周的以医院为基础的教育项目中，2型糖尿病患者的baPWV是否可以改善，以及改善是否与已知的动脉粥样硬化危险因素的变化有关。对32例2型糖尿病患者在营养和锻炼教育前后分别测定体重指数(BMI)、血压(BP)、空腹血糖(FPG)、胰岛素、血脂和BaPWV。并评价BaPWV变化与腹部CT测定的24 h尿C肽排泄量、内脏及皮下脂肪面积、超声测量颈动脉内膜中层厚度(IMT)等指标的关系。BaPWV基线值与年龄、糖尿病病程、血压、IMT、空腹血糖显著相关。治疗后BaPWV显著降低(-120+/-108.4 cm/S，P<0.0001)，并与收缩压(r=0.697，P<0.0001)、空腹血糖(r=0.452，P<0.05)呈显著正相关。这些结果表明，短期住院配合教育计划可以改善动脉壁僵硬，这可能是由于血压和血糖控制的改善。(C)2005爱思唯尔爱尔兰有限公司。保留所有权利。
Brachial-ankle pulse wave velocity (baPWV) is a non-invasive method for assessing arterial stiffness associated with atherosclerosis. We examined whether baPWV could improve during a 2-week hospital-based education program in patients with type 2 diabetes and whether improvement associates with changes in known atherogenic risk factors. Body mass index (BMI), blood pressure (BP), fasting plasma glucose (FPG), insulin, lipid profiles and baPWV were measured in 32 type 2 diabetic patients before and after an educational program that included advice about nutrition and exercise. Relationship between the changes in baPWV and additional parameters, 24 h-urinary excretion of C-peptide, visceral and subcutaneous fat area by abdominal computer tomography and intima-medial thickness (IMT) of the carotid artery by ultrasonography, were also evaluated. Baseline values of baPWV significantly correlated with age, duration of diabetes, BP, IMT and FPG. BaPWV significantly decreased after the program (-120 +/- 108.4 cm/s, P < 0.0001) and this change significantly correlated with that of systolic BP (r = 0.697, P < 0.0001) and FPG (r = 0.452, P < 0.05). These results indicate that short-term hospitalization with an educational program can improve arterial wall stiffness, perhaps due to improvements in BP and glycemic control. (c) 2005 Elsevier Ireland Ltd. All rights reserved.