Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium
Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium
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DOI：
10.1016/j.biopsych.2019.04.022
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发表时间：
2020-06-15
影响因子：
10.6
通讯作者：
Francks, Clyde
中科院分区：
文献类型：
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作者：
Kong, Xiang-Zhen;Boedhoe, Premika S. W.;Francks, Clyde
背景：强迫症（OCD）中存在偏侧性功能障碍。然而，目前尚不清楚强迫症是否以大脑结构不对称的异常模式为特征。在这里，我们进行了什么是迄今为止最大的研究大脑结构不对称的强迫症。方法：我们研究了16个儿童数据集（501例强迫症患者和439名健康对照组），以及30个成人数据集（1777例患者和1654名对照组）的强迫症工作组内的ENIGMA（通过Meta分析增强神经成像遗传学）联盟。皮质下结构体积的不对称性，以及区域皮质厚度和表面积的测量，基于T1加权磁共振成像扫描，使用协调的图像分析和质量控制协议进行评估。我们调查了强迫症患者大脑不对称性的可能改变。我们还探讨了潜在的关联的不对称性与特定方面的障碍和药物治疗status.RESULTS：在儿科数据集，观察到最大的病例对照差异的体积不对称的丘脑（更多的不对称性;科恩的d = 0.19）和苍白球（更少的不对称性; d = -20.21）。进一步的分析表明，这些不对称模式与药物治疗状态、强迫症严重程度或焦虑和抑郁共病之间存在假定的联系。在成人数据集中没有发现显着的病例对照差异。结论：结果表明儿童强迫症的皮质下结构平均不对称性存在细微变化，而在患有该疾病的成人中无法检测到。这些发现可能反映了强迫症的神经发育过程改变。
BACKGROUND: Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD.METHODS: We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status.RESULTS: In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = -20.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets.CONCLUSIONS: The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.