Imprinting disorders and assisted reproductive technology.
Imprinting disorders and assisted reproductive technology.
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DOI：
10.1055/s-0029-1237430
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发表时间：
2009-09
影响因子：
2.7
通讯作者：
Segars JH Jr
中科院分区：
文献类型：
--
作者：
Owen CM;Segars JH Jr
据估计，全世界使用辅助生殖技术（ART）的新生儿占出生人数的1%至3%。自2002年以来，一系列的报告表明，印记疾病（Beckwith-Wiedemann综合征和Angelman综合征）的风险增加ART受孕的儿童。由于印记疾病的罕见性和ART协议的可变性，因此难以证实明确的结论。尽管有这些局限性，有生物学上的可接受性的改变，在非基因组遗传所造成的艺术。动物研究表明，艺术程序可以改变正常的印记，特别是DNA甲基化模式。总的来说，研究表明ART与母体甲基化丧失之间存在关联。最近的报告研究了ART和DNA整体低甲基化之间的可能联系。其他三个印记疾病（银罗素综合征，母亲低甲基化综合征，视网膜母细胞瘤）也有牵连，但没有足够的证据来建立这些综合征与ART的关联。根据目前的证据，ART后印记疾病的绝对风险仍然很小，不需要常规筛查。需要进行大规模的前瞻性研究，以更好地了解与印迹障碍、印迹缺陷和ART相关的风险。
Worldwide use of assisted reproductive technology (ART) accounts for an estimated 1 to 3% of births. Since 2002, a series of reports have suggested an increased risk of imprinting disorders (Beckwith-Wiedemann syndrome and Angelman syndrome) in children conceived by ART. Definitive conclusions are difficult to substantiate due to the rarity of imprinting disorders and the variability in ART protocols. Despite these limitations, there is biological plausibility for alteration in nongenomic inheritance caused by ART. Animal studies have shown that ART procedures can alter normal imprinting, specifically DNA methylation patterns. Collectively, studies suggest an association between ART and loss of maternal methylation. More recent reports examined a possible association between ART and global hypomethylation of DNA. Three other imprinting disorders (Silver-Russell syndrome, maternal hypomethylation syndrome, and retinoblastoma) have also been implicated, but there is insufficient evidence to establish an association of these syndromes with ART. Based on current evidence, the absolute risk of imprinting disorders after ART remains small and does not warrant routine screening. Large prospective studies are needed to better understand the risks associated with imprinting disorders, imprinting defects, and ART.
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DOI：
10.1002/ajmg.1320420440
发表时间：
1992-02-15
期刊：
AMERICAN JOURNAL OF MEDICAL GENETICS
影响因子：
--
作者：
CLAYTONSMITH, J;READ, AP;DONNAI, D
通讯作者：
DONNAI, D
影响因子：
4
作者：
Hartmann, Sonja;Bergmann, Martin;Steger, Klaus
通讯作者：
Steger, Klaus
影响因子：
6.1
作者：
Lim, Derek;Bowdin, Sarah C.;Maher, Eamonn R.
通讯作者：
Maher, Eamonn R.
影响因子：
6.7
作者：
Chang, AS;Moley, KH;DeBaun, MR
通讯作者：
DeBaun, MR
影响因子：
9.8
作者：
Cox, GF;Bürger, J;Horsthemke, B
通讯作者：
Horsthemke, B